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Predicting Recurrence of Wheezing in First Time Wheezers: Serum Cc-16, Periostin, Galectin and YKL-40
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A1430 - Predicting Recurrence of Wheezing in First Time Wheezers: Serum Cc-16, Periostin, Galectin and YKL-40
Author Block: O. Yilmaz1, T. Sarılar2, C. Ulman3, Y. Simsek1, R. Yildiz3, E. Toprak Kanik1, H. Yuksel4; 1Pediatric Allergy and Pulmonology, Celal Bayar Univ, Manisa, Turkey, 2Pediatrics, Celal Bayar Univ, Manisa, Turkey, 3Biochemistry, Celal Bayar Univ, Manisa, Turkey, 4Dept of Pediatric Allergy and Pulmonology, Celal Bayar University, Manisa, Turkey.
Rationale: The aim of this research was to determine; if serum levels of Clara cell protein (CC)-16, periostin, galectin and YKL-40 in children with first episode of wheezing, differ between the ones who do or do not have recurrent wheezing, in six months of follow up. Methods: For this cohort study, we enrolled 152 subjects who presented with first-time wheezing less than three years age. Age, sex, previous history of wheezing and family history were recorded at enrollment as well as the wheezing score at presentation, according to the score used by Gajdos et al previously. Blood samples were obtained from all the subjects at enrollment for measurement of the levels of CC-16, periostin, galectin and YKL-40. Subjects enrolled were followed up for six months and history of wheezing was questioned by face to face interviews with caregivers at intervals of three months and physical examination was performed. Results: Among the 152 children enrolled 22 had recurrent wheezing during follow up. Mean age at presentation was not significantly different between recurrent wheezers and one time wheezers [9.2(7.8) vs 9.9(7.4) respectively, p=0.55, 95%Cİ(-1.7-3.2)]. CC-16, periostin and galectine-3 levels were not significantly different between recurrent and one-time wheezers (p=0.44, p=0.31, p=0.59). YKL-40 levels were higher in the recurrent wheezing group [89.2(75.2)] compared to that in one-time wheezers [59.3(43.3)], but the difference did not reach statistical significance (p=0.06, 95%CI=-60.9-0.9). Conclusion Our results demonstrate; YKL-40 that is a chitinase protein found to be associated with asthma in previous research, may be a promising biomarker to predict recurrent wheezing in children who present with first episode of wheezing. Further cohort studies with higher number of subjects may provide valuable data if different phenotypes of wheezing are considered.
Author Block: O. Yilmaz1, T. Sarılar2, C. Ulman3, Y. Simsek1, R. Yildiz3, E. Toprak Kanik1, H. Yuksel4; 1Pediatric Allergy and Pulmonology, Celal Bayar Univ, Manisa, Turkey, 2Pediatrics, Celal Bayar Univ, Manisa, Turkey, 3Biochemistry, Celal Bayar Univ, Manisa, Turkey, 4Dept of Pediatric Allergy and Pulmonology, Celal Bayar University, Manisa, Turkey.
Rationale: The aim of this research was to determine; if serum levels of Clara cell protein (CC)-16, periostin, galectin and YKL-40 in children with first episode of wheezing, differ between the ones who do or do not have recurrent wheezing, in six months of follow up. Methods: For this cohort study, we enrolled 152 subjects who presented with first-time wheezing less than three years age. Age, sex, previous history of wheezing and family history were recorded at enrollment as well as the wheezing score at presentation, according to the score used by Gajdos et al previously. Blood samples were obtained from all the subjects at enrollment for measurement of the levels of CC-16, periostin, galectin and YKL-40. Subjects enrolled were followed up for six months and history of wheezing was questioned by face to face interviews with caregivers at intervals of three months and physical examination was performed. Results: Among the 152 children enrolled 22 had recurrent wheezing during follow up. Mean age at presentation was not significantly different between recurrent wheezers and one time wheezers [9.2(7.8) vs 9.9(7.4) respectively, p=0.55, 95%Cİ(-1.7-3.2)]. CC-16, periostin and galectine-3 levels were not significantly different between recurrent and one-time wheezers (p=0.44, p=0.31, p=0.59). YKL-40 levels were higher in the recurrent wheezing group [89.2(75.2)] compared to that in one-time wheezers [59.3(43.3)], but the difference did not reach statistical significance (p=0.06, 95%CI=-60.9-0.9). Conclusion Our results demonstrate; YKL-40 that is a chitinase protein found to be associated with asthma in previous research, may be a promising biomarker to predict recurrent wheezing in children who present with first episode of wheezing. Further cohort studies with higher number of subjects may provide valuable data if different phenotypes of wheezing are considered.
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