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A Case of Non-Small Cell Lung Cancer with Accompanying Neuroendocrin Hyperplasia in Pathological Specimen
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A4027 - A Case of Non-Small Cell Lung Cancer with Accompanying Neuroendocrin Hyperplasia in Pathological Specimen
Author Block: D. Dogan Mulazimoglu1, A. Ciledag1, F. Ciftci1, S. Erol1, K. Ceyhan2, O. Kumbasar1; 1Department of Chest Diseases, Ankara University School of Medicine, Department of Chest Diseases, Ankara, Turkey, 2Department of Cytopathology, Ankara University School of Medicine, Department of Cytopathology, Ankara, Turkey.
A 48 year old male patient was admitted with dyspnea, cough and sputum. The patient had a diagnosis of interstitital lung disease for 7 years, without a regular follow-up. He has no smoking history. A chest X-ray revealed an opacity at right lung and thoracic computed tomography (CT) showed a mass with a size of 11x9 cm in the right medial lobe invading thoracic wall. A tru-cut lung biopsy under CT guidance was taken and pathological examination revealed neuroendocrine cell hyperplasia and elastosis. Gallium68 labeled positron emission tomograpy (PET) showed increased uptake in the mass with a SUVmax of 4,4 and in the prevascular, hilar and subcarinal lymph nodes. Because of the atypical radiological findings for neuroendocrine cell hyperplasia and a suspicion of lung cancer, an endobronchial ultrasound guided transbronchial neddle aspiration (EBUS-TBNA) from primary mass and mediastinal lymph nodes was performed. Cytopatological examination showed low differantiated squamos cell lung carcinoma. The patient was evaluated as inoperable, and referred to Medical Oncology Department for chemoradiotherapy.In conclusion, in patients with lung cancer, although extremely rare, neuroendcorine cell hyperplasia may also be accompanied. Hence, in cases with neuroendcorine cell hyperplasia, additional diagnostic procedures may be required to rule out lung cancer to prevent a delay in diagnosis.
Author Block: D. Dogan Mulazimoglu1, A. Ciledag1, F. Ciftci1, S. Erol1, K. Ceyhan2, O. Kumbasar1; 1Department of Chest Diseases, Ankara University School of Medicine, Department of Chest Diseases, Ankara, Turkey, 2Department of Cytopathology, Ankara University School of Medicine, Department of Cytopathology, Ankara, Turkey.
A 48 year old male patient was admitted with dyspnea, cough and sputum. The patient had a diagnosis of interstitital lung disease for 7 years, without a regular follow-up. He has no smoking history. A chest X-ray revealed an opacity at right lung and thoracic computed tomography (CT) showed a mass with a size of 11x9 cm in the right medial lobe invading thoracic wall. A tru-cut lung biopsy under CT guidance was taken and pathological examination revealed neuroendocrine cell hyperplasia and elastosis. Gallium68 labeled positron emission tomograpy (PET) showed increased uptake in the mass with a SUVmax of 4,4 and in the prevascular, hilar and subcarinal lymph nodes. Because of the atypical radiological findings for neuroendocrine cell hyperplasia and a suspicion of lung cancer, an endobronchial ultrasound guided transbronchial neddle aspiration (EBUS-TBNA) from primary mass and mediastinal lymph nodes was performed. Cytopatological examination showed low differantiated squamos cell lung carcinoma. The patient was evaluated as inoperable, and referred to Medical Oncology Department for chemoradiotherapy.In conclusion, in patients with lung cancer, although extremely rare, neuroendcorine cell hyperplasia may also be accompanied. Hence, in cases with neuroendcorine cell hyperplasia, additional diagnostic procedures may be required to rule out lung cancer to prevent a delay in diagnosis.
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