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People with Asthma COPD Overlap Syndrome Have Higher Risk of Obstructive Sleep Apnea Development
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A4786 - People with Asthma COPD Overlap Syndrome Have Higher Risk of Obstructive Sleep Apnea Development
Author Block: X. Liao1, P. Su1, T. Huang1, S. Lin2, C. Shieh2; 1Internal medicine, National Cheng Kung University Hospital, Tainan, Taiwan, 2Institute of clinical medicine, National Cheng Kung University, Tainan, Taiwan.
Rationale: The present study aimed to determine the risk of obstructive sleep apnea (OSA) development induced by asthma-COPD overlap syndrome (ACOS) and the severity of OSA would influence the acute exacerbation rate of ACOS patients.Methods: We conduct a retrospective cohort study. People who had been diagnosed as ACOS during 2000-2011 and had received polysomnography (PSG) for diagnosing obstructive sleep apnea from National Health Insurance Research Database (NHIRD) in Taiwan were enrolled. The Cox proportional hazard regression analysis with adjustment and competing risk regression (CRR) was computed to compare the risk of OSA development in ACOS and non-ACOS patients. The severity of OSA in terms of continuous positive airway pressure (CPAP) use is assessed if it is related to the acute exacerbation rate in ACOS subjects with OSA.Results: 10,622 individuals with ACOS during the period of 2000-2011 is included. The risk of OSA development is calculated for asthma, COPD, ACOS when compared with healthy control, and the adjusted hazard ratios were 3.55 for ACOS (95% CI: 2.89-4.35), 2.54 for asthma and 2.19 for COPD. The ACOS patients who have OSA as well will suffer higher risk at 2.07 folds (95% CI: 1.11-3.85) of acute exacerbation in the future compare with ACOS-alone subjects.Conclusions: In the present study, we demonstrated the risk of OSA development is higher in AOCS group compare with COPD-alone or asthma-alone population. ACOS with OSA will suffer more acute exacerbations compare with ACOS only subjects.
Author Block: X. Liao1, P. Su1, T. Huang1, S. Lin2, C. Shieh2; 1Internal medicine, National Cheng Kung University Hospital, Tainan, Taiwan, 2Institute of clinical medicine, National Cheng Kung University, Tainan, Taiwan.
Rationale: The present study aimed to determine the risk of obstructive sleep apnea (OSA) development induced by asthma-COPD overlap syndrome (ACOS) and the severity of OSA would influence the acute exacerbation rate of ACOS patients.Methods: We conduct a retrospective cohort study. People who had been diagnosed as ACOS during 2000-2011 and had received polysomnography (PSG) for diagnosing obstructive sleep apnea from National Health Insurance Research Database (NHIRD) in Taiwan were enrolled. The Cox proportional hazard regression analysis with adjustment and competing risk regression (CRR) was computed to compare the risk of OSA development in ACOS and non-ACOS patients. The severity of OSA in terms of continuous positive airway pressure (CPAP) use is assessed if it is related to the acute exacerbation rate in ACOS subjects with OSA.Results: 10,622 individuals with ACOS during the period of 2000-2011 is included. The risk of OSA development is calculated for asthma, COPD, ACOS when compared with healthy control, and the adjusted hazard ratios were 3.55 for ACOS (95% CI: 2.89-4.35), 2.54 for asthma and 2.19 for COPD. The ACOS patients who have OSA as well will suffer higher risk at 2.07 folds (95% CI: 1.11-3.85) of acute exacerbation in the future compare with ACOS-alone subjects.Conclusions: In the present study, we demonstrated the risk of OSA development is higher in AOCS group compare with COPD-alone or asthma-alone population. ACOS with OSA will suffer more acute exacerbations compare with ACOS only subjects.
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