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Vitamin D Status and Body Composition of COPD Patients
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A1717 - Vitamin D Status and Body Composition of COPD Patients
Author Block: H. L. Persson1, A. Sioutas2, M. Kentson3, P. K. Jacobson2, M. Forsgren4, P. Lundberg5, O. Dahlqvist-Leinhard6; 1Department of Medical and Health Sciences, Linkoping University, Division of Pulmonary Medicine, University Hospital, Linkoping, Sweden, 2Department of Pulmonary Medicine, University Hospital of Linkoping, Linkoping, Sweden, 3Division of Medicine, Ryhov Hospital, Jonkoping, Sweden, 4Department of Medical and Health Sciences, Linkoping University, Departments of Radiation Physics and Medical and Health Sciences, Linkoping University, Linkoping, Sweden, 5Centre for Medical Image Science and Visualization, Linkoping University, Departments of Radiation Physics and Medical and Health Sciences, Linkoping University, Linkoping, Sweden, 6Centre for Medical Image Science and Visualization, Linkoping University, Advanced MR Analytics (AMRA) AB, Linkoping, Sweden.
BACKGROUND: Previously, we have shown that COPD subjects display a disturbed muscle metabolism associated with an excess of body fat (visceral, abdominal subcutaneous and intramuscular). In the present study the influence of vitamin D status on body composition was investigated. AIMS AND OBJECTIVES: To study variables of body composition [thigh muscle mass (TMM), visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue (ASAT), and intramuscular adipose tissue (IMAT)] in COPD subjects to see how these related to vitamin D status and COPD severity. METHODS: Nine-teen Caucasians with COPD were investigated. Lung function tests and blood sampling were performed. Body composition was assessed using MR. RESULTS: The level of the vitamin D metabolite 25(OH)D correlated positively with FEV1 (L, post-dilatation) and negatively with the level of parathyroid hormone. Subjects exhibiting low levels of 25(OH)D (less than 55 nmol/L) exhibited significantly less VAT and TMM than subjects displaying higher levels of 25(OH)D did. We observed no significant differences between the two groups regarding tobacco exposure, lung function, COPD symptoms (mMRC- and CAT-score), physical activity, blood-glucose, paO2, paCO2, hemoglobin, markers of systemic inflammation (WBC, hs-CRP, IL-6 and fibrinogen), BMI, ASAT and IMAT. CONCLUSION: COPD subjects with low levels of 25(OH)D in serum have less visceral fat and muscle mass than those with higher level.
Author Block: H. L. Persson1, A. Sioutas2, M. Kentson3, P. K. Jacobson2, M. Forsgren4, P. Lundberg5, O. Dahlqvist-Leinhard6; 1Department of Medical and Health Sciences, Linkoping University, Division of Pulmonary Medicine, University Hospital, Linkoping, Sweden, 2Department of Pulmonary Medicine, University Hospital of Linkoping, Linkoping, Sweden, 3Division of Medicine, Ryhov Hospital, Jonkoping, Sweden, 4Department of Medical and Health Sciences, Linkoping University, Departments of Radiation Physics and Medical and Health Sciences, Linkoping University, Linkoping, Sweden, 5Centre for Medical Image Science and Visualization, Linkoping University, Departments of Radiation Physics and Medical and Health Sciences, Linkoping University, Linkoping, Sweden, 6Centre for Medical Image Science and Visualization, Linkoping University, Advanced MR Analytics (AMRA) AB, Linkoping, Sweden.
BACKGROUND: Previously, we have shown that COPD subjects display a disturbed muscle metabolism associated with an excess of body fat (visceral, abdominal subcutaneous and intramuscular). In the present study the influence of vitamin D status on body composition was investigated. AIMS AND OBJECTIVES: To study variables of body composition [thigh muscle mass (TMM), visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue (ASAT), and intramuscular adipose tissue (IMAT)] in COPD subjects to see how these related to vitamin D status and COPD severity. METHODS: Nine-teen Caucasians with COPD were investigated. Lung function tests and blood sampling were performed. Body composition was assessed using MR. RESULTS: The level of the vitamin D metabolite 25(OH)D correlated positively with FEV1 (L, post-dilatation) and negatively with the level of parathyroid hormone. Subjects exhibiting low levels of 25(OH)D (less than 55 nmol/L) exhibited significantly less VAT and TMM than subjects displaying higher levels of 25(OH)D did. We observed no significant differences between the two groups regarding tobacco exposure, lung function, COPD symptoms (mMRC- and CAT-score), physical activity, blood-glucose, paO2, paCO2, hemoglobin, markers of systemic inflammation (WBC, hs-CRP, IL-6 and fibrinogen), BMI, ASAT and IMAT. CONCLUSION: COPD subjects with low levels of 25(OH)D in serum have less visceral fat and muscle mass than those with higher level.
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