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E-Cigarette Use Is Associated with Emphysema, Chronic Bronchitis and COPD
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A6245 - E-Cigarette Use Is Associated with Emphysema, Chronic Bronchitis and COPD
Author Block: M. F. Perez, N. Atuegwu, E. Mead, C. Oncken, E. M. Mortensen; Internal Medicine, UConn Health, Farmington, CT, United States.
Background: There has been an exponential increase in the use of electronic cigarettes (E-cig) in the United States and this has raised concerns about the effects of these products on lung health. Recent publications have shown an association between E-cig use and asthma in youths. In-vitro and animal studies have shown an inflammatory response to E-cigs similar to conventional cigarettes, which can lead to chronic obstructive pulmonary disease (COPD.) The purpose of this study is to examine the association between E-cig use and COPD in adults.
Methods: Adult 2013-2014 Population Assessment of Tobacco and Health (PATH) Study data was used for the analyses. E-cig use was defined as fairly regular use of E-cigs every day or some days and the prevalence of COPD was defined as having either emphysema, chronic bronchitis or COPD. Propensity score matching was used to balance potential confounders (e.g. use of other tobacco products, second-hand smoke) between the E-cig and non E-cig users. Logistic regression was then used to examine the association between E-cig use and COPD, while also adjusting for potential confounders. We utilized replicate weights and balanced repeated replication methods to account for the PATH Study’s complex survey design.
Results: 1,575 out of 32,247 people that participated in the survey met the criteria for E-cig use. The prevalence of COPD among E-cig users was 4.45% (95% confidence interval [CI] 3.70-5.19). The propensity-matched group was composed of 1321 E-cig users and 1321 non E-cig users. E-cig users had increased odds of having COPD odds ratio 1.86 95% confidence interval 1.22-2.83.
Conclusion: We showed that fairly regular use of E-cigs every day or some days is associated with an increased odds of having COPD in a large representative US adult cohort. This association exists even after adjusting for potential confounding factors. Due to the fact that the data is cross-sectional, it is unknown whether E-cigs could contribute to COPD development, or if people who have COPD are more likely to use E-cigs (possibly as a harm reduction method). Prospective data are needed to better determine the nature of this association.
Author Block: M. F. Perez, N. Atuegwu, E. Mead, C. Oncken, E. M. Mortensen; Internal Medicine, UConn Health, Farmington, CT, United States.
Background: There has been an exponential increase in the use of electronic cigarettes (E-cig) in the United States and this has raised concerns about the effects of these products on lung health. Recent publications have shown an association between E-cig use and asthma in youths. In-vitro and animal studies have shown an inflammatory response to E-cigs similar to conventional cigarettes, which can lead to chronic obstructive pulmonary disease (COPD.) The purpose of this study is to examine the association between E-cig use and COPD in adults.
Methods: Adult 2013-2014 Population Assessment of Tobacco and Health (PATH) Study data was used for the analyses. E-cig use was defined as fairly regular use of E-cigs every day or some days and the prevalence of COPD was defined as having either emphysema, chronic bronchitis or COPD. Propensity score matching was used to balance potential confounders (e.g. use of other tobacco products, second-hand smoke) between the E-cig and non E-cig users. Logistic regression was then used to examine the association between E-cig use and COPD, while also adjusting for potential confounders. We utilized replicate weights and balanced repeated replication methods to account for the PATH Study’s complex survey design.
Results: 1,575 out of 32,247 people that participated in the survey met the criteria for E-cig use. The prevalence of COPD among E-cig users was 4.45% (95% confidence interval [CI] 3.70-5.19). The propensity-matched group was composed of 1321 E-cig users and 1321 non E-cig users. E-cig users had increased odds of having COPD odds ratio 1.86 95% confidence interval 1.22-2.83.
Conclusion: We showed that fairly regular use of E-cigs every day or some days is associated with an increased odds of having COPD in a large representative US adult cohort. This association exists even after adjusting for potential confounding factors. Due to the fact that the data is cross-sectional, it is unknown whether E-cigs could contribute to COPD development, or if people who have COPD are more likely to use E-cigs (possibly as a harm reduction method). Prospective data are needed to better determine the nature of this association.
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