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COPD-Related Mortality and Co-Morbidities in the United States of America, 1999-2015: A Multiple Causes of Death Analysis
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A3550 - COPD-Related Mortality and Co-Morbidities in the United States of America, 1999-2015: A Multiple Causes of Death Analysis
Author Block: J. I. Obi; Pulmonary disease, Howard University Hospital, Washington, DC, United States.
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) mortality based on the underlying cause of death (UCOD) underestimates disease burden. We aimed to determine the current COPD mortality rate, trends and the distribution of co-morbidities using United States (US) multiple-cause of death (MCOD) records. METHODS: All, 38,905,575 death certificates with any mention of COPD of decedents aged ≥ 45 years in the US were analyzed for 1999-2015. COPD was defined by ICD-10 codes J40-J44 and J47 based either on the UCOD or MCOD. Annual age-standardized COPD death rates were computed according to age, gender and race/ethnicity. RESULTS: In 2015, COPD was mentioned in 11.59% (292,572 deaths) in MCOD, compared to 11.13% (243,617 deaths) in 1999, a 4% increase. However, it was reported as the UCOD for only 5.56% and 4.97% in 2015 and 1999 respectively. The most common UCOD in subjects with any mention of COPD was respiratory disorders in 49% of males and 55% of females. The rates for MCOD decreased in men and increased in females over the years. For example, amongst non-Hispanic whites, the rates for MCOD decreased from 172.5 per 100,000 to 142.6 per 100,000 (-17%) in males, but the rate increased from 111.8 per 100,000 to 124.0 per 100,000 (+11%) in females. CONCLUSIONS: UCOD underestimated the burden of COPD in the United States. Our analysis showed that MCOD was twice as high as UCOD across the years. Though both showed the rate of deaths from COPD decreased among men, but continued to increase among women. MCOD analysis should be adopted to fully evaluate the burden of COPD-related mortality.
Author Block: J. I. Obi; Pulmonary disease, Howard University Hospital, Washington, DC, United States.
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) mortality based on the underlying cause of death (UCOD) underestimates disease burden. We aimed to determine the current COPD mortality rate, trends and the distribution of co-morbidities using United States (US) multiple-cause of death (MCOD) records. METHODS: All, 38,905,575 death certificates with any mention of COPD of decedents aged ≥ 45 years in the US were analyzed for 1999-2015. COPD was defined by ICD-10 codes J40-J44 and J47 based either on the UCOD or MCOD. Annual age-standardized COPD death rates were computed according to age, gender and race/ethnicity. RESULTS: In 2015, COPD was mentioned in 11.59% (292,572 deaths) in MCOD, compared to 11.13% (243,617 deaths) in 1999, a 4% increase. However, it was reported as the UCOD for only 5.56% and 4.97% in 2015 and 1999 respectively. The most common UCOD in subjects with any mention of COPD was respiratory disorders in 49% of males and 55% of females. The rates for MCOD decreased in men and increased in females over the years. For example, amongst non-Hispanic whites, the rates for MCOD decreased from 172.5 per 100,000 to 142.6 per 100,000 (-17%) in males, but the rate increased from 111.8 per 100,000 to 124.0 per 100,000 (+11%) in females. CONCLUSIONS: UCOD underestimated the burden of COPD in the United States. Our analysis showed that MCOD was twice as high as UCOD across the years. Though both showed the rate of deaths from COPD decreased among men, but continued to increase among women. MCOD analysis should be adopted to fully evaluate the burden of COPD-related mortality.
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