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NFE2L2 Polymorphisms Associated with Susceptibility to Tuberculosis in Chinese Tibetan Population
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A4310 - NFE2L2 Polymorphisms Associated with Susceptibility to Tuberculosis in Chinese Tibetan Population
Author Block: J. He; Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China, Chengdu, China.
RATIONALE: Previous studies have suggested that tuberculosis (TB) is associated with an imbalance between oxidant and antioxidant responses. Nuclear factor-erythroid 2 (NF-E2)-related factor 2 (Nrf2), encoded by NFE2L2, is a critical transcription factor in the anti-oxidation process. This study aimed to investigate the association of NFE2L2 single nucleotide polymorphisms (SNPs) with TB susceptibility in Chinese Tibetan population. METHODS: 1216 Tibetan population including 603 healthy control and 613 Tibetan TB cases were recruited. TagSNPs of NFE2L2 were selected based on the HapMap database by the Haploview software and were genotyped by the SNPscanTM Kit. Haploview software 4.2 and online software SHEsis were applied to analyze linkage disequilibrium (LD) and haplotypes of tagSNPs. The effects of gene-gene and gene-environment interactions were analyzed using nonparametric multifactor dimensionality reduction (MDR) method. RESULTS: After adjusting for covariants, in the Tibetan population, allele A of rs1962142, genotype AA of rs6726395 demonstrated to increase TB risk (p=0.028,OR 95%CI 1.23(1.02-1.48) and p=0.001,OR95%CI 1.7(1.23-2.35)), above association was also shown in the female subgroup for rs1962142(p=0.021, OR 1.40) and in the male subgroup for rs6726395 (p=0.002,OR 1.99). Instead, rs2364723 C protected against TB (p=0.009, OR 95%CI 0.81(0.69-0.95)), as well as displayed in the female subgroup (p=0.007, OR 0.72). In addition, rs10497511 G elevated susceptibility to TB in the female subgroup (p=0.019, OR95%CI 1.40(1.06-1.84)). Frequency of haplotype ATC of rs10497511-rs13005431-rs2364723 was significant lower in the TB patients (p=0.008, OR95%CI 0.804 (0.684-0.945)). No significant finding was observed after MDR analysis. CONCLUSIONS: Our study suggested that NFE2L2 variants might be related with TB susceptibility in Chinese Tibetan population.
Author Block: J. He; Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China, Chengdu, China.
RATIONALE: Previous studies have suggested that tuberculosis (TB) is associated with an imbalance between oxidant and antioxidant responses. Nuclear factor-erythroid 2 (NF-E2)-related factor 2 (Nrf2), encoded by NFE2L2, is a critical transcription factor in the anti-oxidation process. This study aimed to investigate the association of NFE2L2 single nucleotide polymorphisms (SNPs) with TB susceptibility in Chinese Tibetan population. METHODS: 1216 Tibetan population including 603 healthy control and 613 Tibetan TB cases were recruited. TagSNPs of NFE2L2 were selected based on the HapMap database by the Haploview software and were genotyped by the SNPscanTM Kit. Haploview software 4.2 and online software SHEsis were applied to analyze linkage disequilibrium (LD) and haplotypes of tagSNPs. The effects of gene-gene and gene-environment interactions were analyzed using nonparametric multifactor dimensionality reduction (MDR) method. RESULTS: After adjusting for covariants, in the Tibetan population, allele A of rs1962142, genotype AA of rs6726395 demonstrated to increase TB risk (p=0.028,OR 95%CI 1.23(1.02-1.48) and p=0.001,OR95%CI 1.7(1.23-2.35)), above association was also shown in the female subgroup for rs1962142(p=0.021, OR 1.40) and in the male subgroup for rs6726395 (p=0.002,OR 1.99). Instead, rs2364723 C protected against TB (p=0.009, OR 95%CI 0.81(0.69-0.95)), as well as displayed in the female subgroup (p=0.007, OR 0.72). In addition, rs10497511 G elevated susceptibility to TB in the female subgroup (p=0.019, OR95%CI 1.40(1.06-1.84)). Frequency of haplotype ATC of rs10497511-rs13005431-rs2364723 was significant lower in the TB patients (p=0.008, OR95%CI 0.804 (0.684-0.945)). No significant finding was observed after MDR analysis. CONCLUSIONS: Our study suggested that NFE2L2 variants might be related with TB susceptibility in Chinese Tibetan population.
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