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Survival After Respiratory Hospitalization for Acute Exacerbation and Non-Acute Exacerbation in IPF
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A1658 - Survival After Respiratory Hospitalization for Acute Exacerbation and Non-Acute Exacerbation in IPF
Author Block: O. Nishiyama1, R. Yamazaki1, S. Saeki1, H. Sano1, T. Iwanaga2, Y. Higashimoto1, H. Kume2, Y. Tohda2; 1Department of Respiratory Medicine and Allergology, Kindai University, Faculty of Medicine, Osaka, Japan, 2Kindai University, Faculty of Medicine, Osaka, Japan.
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive disease with a poor prognosis. Recently, it has been reported that respiratory-related hospitalization often occurs and it is associated with subsequent survival in IPF. Respiratory hospitalization (RH) in IPF includes acute exacerbation (AE) of IPF and others. The purpose of this study was to compare the prognostic value of RH for AE and non-AE in IPF. METHODS: One hundred and sixty-eight consecutive patients with IPF who underwent evaluation as general practice in our University hospital between January 2008 and August 2017 and were followed-up thereafter were included in the study. The occurence of RH and the survival after the RH were retrospectively reviewed. The diagnosis of IPF was made according to the ATS/ERS/JRS/ALAT consensus statement 2011. The diagnosis of AE of IPF was made according to the ATS international working report 2016. RESULTS: The mean follow-up period was 984±743 days (range of 2 to 3350 days), and 89 patients (52.9%) were deceased. Seventy-five patients (44.6%) experienced unscheduled RH for the first time during the observation period. The RHs included 26 AEs (34.7%) and 49 non-AEs (65.3%). Non-AE RH includes 25 pulmonary infection (33.3%), 8 pneumothorax (10.6%), 6 chronic worsening with decrease in oxygenation (8.0%), 5 right heart failure (6.6%), and 5 others (6.6%). The 50% survival times after RH were 463±87 and 444±33 days for AE and non-AE RH, respectively (Log-rank p=0.33). CONCLUSIONS: The survival after RH was poor in IPF. Pulmonary infection was the majority of the causes for non-AE RH. The survival after non-AE RH is poor so as to be equal to that after AE RH.
Author Block: O. Nishiyama1, R. Yamazaki1, S. Saeki1, H. Sano1, T. Iwanaga2, Y. Higashimoto1, H. Kume2, Y. Tohda2; 1Department of Respiratory Medicine and Allergology, Kindai University, Faculty of Medicine, Osaka, Japan, 2Kindai University, Faculty of Medicine, Osaka, Japan.
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive disease with a poor prognosis. Recently, it has been reported that respiratory-related hospitalization often occurs and it is associated with subsequent survival in IPF. Respiratory hospitalization (RH) in IPF includes acute exacerbation (AE) of IPF and others. The purpose of this study was to compare the prognostic value of RH for AE and non-AE in IPF. METHODS: One hundred and sixty-eight consecutive patients with IPF who underwent evaluation as general practice in our University hospital between January 2008 and August 2017 and were followed-up thereafter were included in the study. The occurence of RH and the survival after the RH were retrospectively reviewed. The diagnosis of IPF was made according to the ATS/ERS/JRS/ALAT consensus statement 2011. The diagnosis of AE of IPF was made according to the ATS international working report 2016. RESULTS: The mean follow-up period was 984±743 days (range of 2 to 3350 days), and 89 patients (52.9%) were deceased. Seventy-five patients (44.6%) experienced unscheduled RH for the first time during the observation period. The RHs included 26 AEs (34.7%) and 49 non-AEs (65.3%). Non-AE RH includes 25 pulmonary infection (33.3%), 8 pneumothorax (10.6%), 6 chronic worsening with decrease in oxygenation (8.0%), 5 right heart failure (6.6%), and 5 others (6.6%). The 50% survival times after RH were 463±87 and 444±33 days for AE and non-AE RH, respectively (Log-rank p=0.33). CONCLUSIONS: The survival after RH was poor in IPF. Pulmonary infection was the majority of the causes for non-AE RH. The survival after non-AE RH is poor so as to be equal to that after AE RH.
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