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Do Raised Serum Ige and Eosinophils Have an Affect on Quality of Life and Patient Related Outcome in COPD?
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A4765 - Do Raised Serum Ige and Eosinophils Have an Affect on Quality of Life and Patient Related Outcome in COPD?
Author Block: A. J. Yousuf1, S. Parker1, J. Finch1, G. Parekh2, S. Glover1, L. Watson1, L. Beadle1, C. White1, C. E. Brightling3; 1Infection, Immunity and Inflamation, University of Leicester, Leicester, United Kingdom, 2Mologic Ltd, Thurleigh, United Kingdom, 3Infection, Immunity, Inflammation, University of Leicester, Maurice Shock Medical School, Leicester, United Kingdom.
Background Chronic obstructive pulmonary disease (COPD) is a common, preventable and treatable condition characterised by airflow limitation that is irreversible and usually progressive. In this prospective study we aimed to assess the relationship between total serum IgE, blood eosinophils, quality of life and patient related outcome (PRO). Method Subjects with COPD diagnosed according to GOLD guidelines were recruited as part of a biomarker validation observational study. Fifty patients with physician diagnosed COPD were evaluated by measuring total serum IgE, blood eosinophils, St. George’s Respiratory Questionnaire (SGRQ) , COPD assessment test (CAT) questionnaire and MRC dyspnea score as surrogates for quality of life measure and PRO, respectively. Results The mean age of the participants was 68 years (SEM [1.16], range [55-85] years). The mean total serum IgE was 435 (normal range [0-81 kU/L], SEM [156]) and the mean peripheral blood eosinophil count was 240 (normal range [0-200cell/µl], SEM [38]). Using ranked Spearman correlation values there were no statistically significant correlations between total serum IgE and SGRQ (r = -0.00017, p= 1.0), CAT (r= -0.0005, p= 1.0) and MRC dyspnea scores ( r= -0.08, p= 0.52). There was also no statistically significant correlation between peripheral blood eosinophils and SGRQ ( r= 0.07, p= 0.63), CAT ( r=0.18, p= 0.22) and MRC dyspnea scores ( r=0.19, p= 0.18). Conclusion: There does not seem to be a statistically significant correlation between raised total serum IgE, raised peripheral blood eosinophils, health status and patient related outcomes in COPD.
Author Block: A. J. Yousuf1, S. Parker1, J. Finch1, G. Parekh2, S. Glover1, L. Watson1, L. Beadle1, C. White1, C. E. Brightling3; 1Infection, Immunity and Inflamation, University of Leicester, Leicester, United Kingdom, 2Mologic Ltd, Thurleigh, United Kingdom, 3Infection, Immunity, Inflammation, University of Leicester, Maurice Shock Medical School, Leicester, United Kingdom.
Background Chronic obstructive pulmonary disease (COPD) is a common, preventable and treatable condition characterised by airflow limitation that is irreversible and usually progressive. In this prospective study we aimed to assess the relationship between total serum IgE, blood eosinophils, quality of life and patient related outcome (PRO). Method Subjects with COPD diagnosed according to GOLD guidelines were recruited as part of a biomarker validation observational study. Fifty patients with physician diagnosed COPD were evaluated by measuring total serum IgE, blood eosinophils, St. George’s Respiratory Questionnaire (SGRQ) , COPD assessment test (CAT) questionnaire and MRC dyspnea score as surrogates for quality of life measure and PRO, respectively. Results The mean age of the participants was 68 years (SEM [1.16], range [55-85] years). The mean total serum IgE was 435 (normal range [0-81 kU/L], SEM [156]) and the mean peripheral blood eosinophil count was 240 (normal range [0-200cell/µl], SEM [38]). Using ranked Spearman correlation values there were no statistically significant correlations between total serum IgE and SGRQ (r = -0.00017, p= 1.0), CAT (r= -0.0005, p= 1.0) and MRC dyspnea scores ( r= -0.08, p= 0.52). There was also no statistically significant correlation between peripheral blood eosinophils and SGRQ ( r= 0.07, p= 0.63), CAT ( r=0.18, p= 0.22) and MRC dyspnea scores ( r=0.19, p= 0.18). Conclusion: There does not seem to be a statistically significant correlation between raised total serum IgE, raised peripheral blood eosinophils, health status and patient related outcomes in COPD.
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