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A1980 - Clinical Characteristics of Patients with Coinfection of Mycobacterium Aviam Complex and Mycobacterium Gordonae
Author Block: K. Isomoto, E. Hagiwara, H. Yamakawa, T. Oda, T. Katano, G. Matama, R. Shintani, S. Sadoyama, A. Naoto, R. Otoshi, E. Tabata, S. Ikeda, H. Nakagawa, R. Okuda, A. Sekine, T. Niwa, H. Kitamura, T. Baba, S. Komatsu, T. Ogura; Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.
RATIONALE: Mycobacterium gordonae is generally a low pathogenic organism and sometimes regarded as contamination. Although M.gordonae is often isolated with other nontuberculous mycobacteria species simultaneously or alternately, little is known about its clinical significance and characteristics of those coinfection cases. METHODS: We retrospectively reviewed the medical records of all 69 patients with M. gordonae lung disease during 2006 and 2015 at our institution. We identified patients with multiple positive culture of Mycobacterium avium complex (MAC) and analyzed clinical, radiological, and microbiological data. RESULTS: We identified 22 M. gordonae lung disease patients with multiple positive culture of MAC. The median age was 68 years (range, 54-80 yr) and 73% of patients were female. Radiological features showed nodular-bronchiectatic disease in 15 patients (68%), fibrocavitary disease in 4 patients (18%), and others in 3 patients (14%). Thirteen patients (59%) had a history of prior treatment of nontuberculous mycobacteriosis or tuberculosis. Isolation patterns of these two mycobacteria were simultaneous in 14 patients (64%) and alternately substituted in 8 patients (36%). Among 8 cases with alternate substitution by other mycobacterium, 6 patients had a history of multidrug treatment. CONCLUSIONS: Nearly one-third of patients with M.gordonae lung disease had coinfections with MAC. Prior treatment history may be related to mycobacterial coinfection or substitution.