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The Correlation of VE/VCO2 Slope with the Bode Index and Quality of Life in Patients with COPD
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A5041 - The Correlation of VE/VCO2 Slope with the Bode Index and Quality of Life in Patients with COPD
Author Block: M. Mirdamadi1, B. Rahimi2, M. Arabian1; 1Shahid Rajaiee Hospital, Tehran, Iran, Islamic Republic of, 2University of Tehran, Tehran, Iran, Islamic Republic of.
Introduction: The predictive value of cardiopulmonary exercise test measurements regarding quality of life outcomes in Chronic Obstructive Pulmonary Disease (COPD) has not been well described. Quality of life is impaired in patients with COPD and it has been shown that increasing COPD severity is associated with a significantly greater score in St George’s respiratory questionnaire for COPD patients (SGRQ-C). The minute ventilation/carbon dioxide production (VE/VCO2) slope, acquire during exercise testing, has prognostic value which is obtained with BODE (Body-mass index, airflow Obstruction, Dyspnea, and Exercise) index in COPD patients. The BODE Index is used to predict mortality. Patients with a higher BODE Index have a higher risk of respiratory and any cause of death (respiratory failure, pneumonia or pulmonary embolism) and have a greater number of COPD exacerbations and hospitalizations. In this study we retrospectively evaluated the association between VE/VCO2 slope and BODE Index in stable COPD patients who performed CPET.
METHODS: 37 patients with stable COPD (BMI =26.19+_4.81 and mean age =56.8) have been enrolled to the study. All of patient was undergo cardiology assessments (ECG, Echocardiography) and they did not have any carcinogenic disease. To identify quality of life (symptoms, activity limitation and Impact), the SGRQ-C score was used. An empirical model was applied for calculating BODE index: for each threshold value of FEV1, distance walked in six minutes, and score on the Modified Medical Research Council Dyspnea (MMRC). For BODE index, the points of each variable (Body-mass index, airflow Obstruction, Dyspnea, and Exercise) ranged from 0 to 10 points, with higher scores indicating a greater risk of death.
RESULTS: The spirometry results before CPET showed the 66.78+_22% for FEV1. There was significant positive correlation between VE/VCO2 slope and SGRQ-C score (P⩽ 0.01). Although positive partial correlation between VE/VCO2 slope and SGRQ-C score (Activity and Impact score) controlled by SPO2 at the end of 6MWT was significant (P⩽ 0.05). Also VE/VCO2 slope and BODE index had significant adjusted correlation controlled by SPO2 at the end of 6MWT. (P⩽ 0.05)
CONCLUSIONS: The aim of this study was to find whether a poor ventilatory efficiency is associated with Activity, Impacts and quality of life in these patients. With consideration to the significant correlation between VE/VCO2 slope and BODE index it could be suggested that, CPET, could be applied for prognosis assessment. Further studies will be performed to clarify the importance of CPET to determine the prognosis in COPD patients.
Author Block: M. Mirdamadi1, B. Rahimi2, M. Arabian1; 1Shahid Rajaiee Hospital, Tehran, Iran, Islamic Republic of, 2University of Tehran, Tehran, Iran, Islamic Republic of.
Introduction: The predictive value of cardiopulmonary exercise test measurements regarding quality of life outcomes in Chronic Obstructive Pulmonary Disease (COPD) has not been well described. Quality of life is impaired in patients with COPD and it has been shown that increasing COPD severity is associated with a significantly greater score in St George’s respiratory questionnaire for COPD patients (SGRQ-C). The minute ventilation/carbon dioxide production (VE/VCO2) slope, acquire during exercise testing, has prognostic value which is obtained with BODE (Body-mass index, airflow Obstruction, Dyspnea, and Exercise) index in COPD patients. The BODE Index is used to predict mortality. Patients with a higher BODE Index have a higher risk of respiratory and any cause of death (respiratory failure, pneumonia or pulmonary embolism) and have a greater number of COPD exacerbations and hospitalizations. In this study we retrospectively evaluated the association between VE/VCO2 slope and BODE Index in stable COPD patients who performed CPET.
METHODS: 37 patients with stable COPD (BMI =26.19+_4.81 and mean age =56.8) have been enrolled to the study. All of patient was undergo cardiology assessments (ECG, Echocardiography) and they did not have any carcinogenic disease. To identify quality of life (symptoms, activity limitation and Impact), the SGRQ-C score was used. An empirical model was applied for calculating BODE index: for each threshold value of FEV1, distance walked in six minutes, and score on the Modified Medical Research Council Dyspnea (MMRC). For BODE index, the points of each variable (Body-mass index, airflow Obstruction, Dyspnea, and Exercise) ranged from 0 to 10 points, with higher scores indicating a greater risk of death.
RESULTS: The spirometry results before CPET showed the 66.78+_22% for FEV1. There was significant positive correlation between VE/VCO2 slope and SGRQ-C score (P⩽ 0.01). Although positive partial correlation between VE/VCO2 slope and SGRQ-C score (Activity and Impact score) controlled by SPO2 at the end of 6MWT was significant (P⩽ 0.05). Also VE/VCO2 slope and BODE index had significant adjusted correlation controlled by SPO2 at the end of 6MWT. (P⩽ 0.05)
CONCLUSIONS: The aim of this study was to find whether a poor ventilatory efficiency is associated with Activity, Impacts and quality of life in these patients. With consideration to the significant correlation between VE/VCO2 slope and BODE index it could be suggested that, CPET, could be applied for prognosis assessment. Further studies will be performed to clarify the importance of CPET to determine the prognosis in COPD patients.
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