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Is the Mechanical Load Induced by Rostral Fluid Shift on the Upper Airways Compensated by a Cortical Activity During Wakefulness?
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A2422 - Is the Mechanical Load Induced by Rostral Fluid Shift on the Upper Airways Compensated by a Cortical Activity During Wakefulness?
Author Block: C. Launois1, T. Similowski1, I. Arnulf2, E. Perger2, S. Redolfi2; 1Sorbonne Université, UPMC Univ Paris 06, INSERM, UMRS 1158 Neurophysiologie respiratoire expérimentale et clinique, Paris, France, 2AP-HP, Groupe Hospitalier Pitié-Salpêtrière Charles Foix, Service de Pathologies du Sommeil, Paris, France.
Objective: We have previously shown that patients with obstructive sleep apnea (OSA) have a respiratory-related cortical activity during wakefulness in sitting position. This cortical activity appears on the electroencephalogram (EEG) as a pre-inspiratory potentials (PIP) and might contribute to maintain upper airway patent during wakefulness in patients with OSA. It is well known that overnight rostral fluid shift (RFS) from the legs to the neck increases the mechanical load on the upper airways inducing OSA. Our objective was to investigate if RFS induced during wakefulness causes a cortical activation as determined by the presence of PIP.
Methods: Non-obese healthy men were enrolled in the study. During wakefulness, the RFS was measured by bioelectrical impedance after the passage from the sitting to the supine position and after the application of lower body positive pressure (LBPP). The EEG was analyzed during the different phases to detect the presence of PIP.
Results: Twelve healthy men (median ± interquartile range age 27±6 years; body mass index (BMI) 21.7±4.6 kg/m²) were included. The RFS was 410±140 ml in the passage from the sitting to the supine position and 95±143 ml after the application of LBPP. PIP was observed in 1 subject while sitting, in 5 subjects in the supine position and in 0 subject after the application of LBPP. Subjects that showed a PIP in the supine position had a higher RFS from the sitting to the supine position than subjects without PIP in supine position (440±90 ml vs 320±45 ml, p=0.02), without any difference in age and BMI.
Conclusion: In awake healthy subjects the passage from the sitting to the supine position induces a RFS that is associated with the occurrence of a transitory cortical compensation.
Author Block: C. Launois1, T. Similowski1, I. Arnulf2, E. Perger2, S. Redolfi2; 1Sorbonne Université, UPMC Univ Paris 06, INSERM, UMRS 1158 Neurophysiologie respiratoire expérimentale et clinique, Paris, France, 2AP-HP, Groupe Hospitalier Pitié-Salpêtrière Charles Foix, Service de Pathologies du Sommeil, Paris, France.
Objective: We have previously shown that patients with obstructive sleep apnea (OSA) have a respiratory-related cortical activity during wakefulness in sitting position. This cortical activity appears on the electroencephalogram (EEG) as a pre-inspiratory potentials (PIP) and might contribute to maintain upper airway patent during wakefulness in patients with OSA. It is well known that overnight rostral fluid shift (RFS) from the legs to the neck increases the mechanical load on the upper airways inducing OSA. Our objective was to investigate if RFS induced during wakefulness causes a cortical activation as determined by the presence of PIP.
Methods: Non-obese healthy men were enrolled in the study. During wakefulness, the RFS was measured by bioelectrical impedance after the passage from the sitting to the supine position and after the application of lower body positive pressure (LBPP). The EEG was analyzed during the different phases to detect the presence of PIP.
Results: Twelve healthy men (median ± interquartile range age 27±6 years; body mass index (BMI) 21.7±4.6 kg/m²) were included. The RFS was 410±140 ml in the passage from the sitting to the supine position and 95±143 ml after the application of LBPP. PIP was observed in 1 subject while sitting, in 5 subjects in the supine position and in 0 subject after the application of LBPP. Subjects that showed a PIP in the supine position had a higher RFS from the sitting to the supine position than subjects without PIP in supine position (440±90 ml vs 320±45 ml, p=0.02), without any difference in age and BMI.
Conclusion: In awake healthy subjects the passage from the sitting to the supine position induces a RFS that is associated with the occurrence of a transitory cortical compensation.
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