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Comparison of Immunoglobulins in COPD Patients Between with and Without Bronchiectasis
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A5045 - Comparison of Immunoglobulins in COPD Patients Between with and Without Bronchiectasis
Author Block: J. Park, J. Lee, E. Heo, H. Chung, D. Kim; Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea, Republic of.
Objective: COPD patients complicated with concurrent bronchiectasis (BE) seemed to present more acute exacerbation and worse clinical course. Meanwhile, several previous presented lower amount of serum immunoglobulin(Ig) in COPD patients. In this report, we compared clinical features COPD patients according to the presence of BE and further, we analyzed the serum Ig level between COPD patients with and without BE in each subtype of Ig. Methods: Retrospective analyses of COPD registry of tertiary referral respiratory center were performed. Detailed history and examination such as pulmonary function test were assessed. Amount of serum Ig were identified with commercially available ELSIA kit and was compared between patients with and without BE. Results: The subjects were composed of 80 COPD patients, 71.61±8.63 years old in average and 76(95%) were males. 22 patients (27.5%) had concurrent BE. FEV1 was 61.10±17.00 %, FVC was 88.70±15.98 % and FEV1/FVC was 48.30±11.29%. Total amounts of IgG, IgE, IgA and IgM were 1433.62±783.52 mg/dl, 0.03±0.06 md/dl, 148.49±59.81 mg/dl and 292.94±210.06 md/dl respectively. The amount of immunoglobulin presented no significant difference according to BE (IgG;p=0.648, IgE;p=0.217 and IgA;p=0.282). COPD patients with BE presented no significant difference with patients without BE in FEV1/FVC (p=0.276) or FEV (p=0.779). Conclusion: COPD patients with BE presented no significant difference not only in the amounts of immunoglobulin, but also in pulmonary function test when compared with patients without BE.
Author Block: J. Park, J. Lee, E. Heo, H. Chung, D. Kim; Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea, Republic of.
Objective: COPD patients complicated with concurrent bronchiectasis (BE) seemed to present more acute exacerbation and worse clinical course. Meanwhile, several previous presented lower amount of serum immunoglobulin(Ig) in COPD patients. In this report, we compared clinical features COPD patients according to the presence of BE and further, we analyzed the serum Ig level between COPD patients with and without BE in each subtype of Ig. Methods: Retrospective analyses of COPD registry of tertiary referral respiratory center were performed. Detailed history and examination such as pulmonary function test were assessed. Amount of serum Ig were identified with commercially available ELSIA kit and was compared between patients with and without BE. Results: The subjects were composed of 80 COPD patients, 71.61±8.63 years old in average and 76(95%) were males. 22 patients (27.5%) had concurrent BE. FEV1 was 61.10±17.00 %, FVC was 88.70±15.98 % and FEV1/FVC was 48.30±11.29%. Total amounts of IgG, IgE, IgA and IgM were 1433.62±783.52 mg/dl, 0.03±0.06 md/dl, 148.49±59.81 mg/dl and 292.94±210.06 md/dl respectively. The amount of immunoglobulin presented no significant difference according to BE (IgG;p=0.648, IgE;p=0.217 and IgA;p=0.282). COPD patients with BE presented no significant difference with patients without BE in FEV1/FVC (p=0.276) or FEV (p=0.779). Conclusion: COPD patients with BE presented no significant difference not only in the amounts of immunoglobulin, but also in pulmonary function test when compared with patients without BE.
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