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The Potential Role of Serum TGF-β as a Biomarker for Asthma
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A1335 - The Potential Role of Serum TGF-β as a Biomarker for Asthma
Author Block: S. Miyoshi1, H. Nagase1, M. Ujino1, A. Ito1, H. Sakasegawa1, T. Esaki1, K. Kobayashi1, Y. Koizumi1, Y. Tanaka1, N. Sugimoto2, M. Kuramochi1, H. Arai1, M. Yamaguchi1, K. Ohta3; 1Division of Respiratory Medicine and Allergology, Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan, 2Department of Respiratory Medicine, Kanto Central Hospital for Public School Teachers, Tokyo, Japan, 3Tokyo National Hospital, Tokyo, Japan.
(Background) Transforming Growth Factor (TGF)-β is a fibrogenic factor, which may induce airway remodeling in asthma. In contrast, TGF-β also has an immunosuppressive role by inducing the differentiation of regulatory T cells. To date, the significance of measuring TGF-β in asthma has not been established yet. In this study, we investigated the relationship between the level of serum TGF-β and clinical background and other established biomarkers in asthma.
(Methods) Patients were recruited from the outpatient clinic of Teikyo University Hospital (n=243). The levels of serum TGF-β was measured by ELISA and the relationship between serum TGF-β and patient background, asthma control test (ACT) score, pulmonary function, peripheral eosinophil count, FeNO, and serum periostin was investigated.
(Results) The level of serum TGF-β was significantly higher in atopic asthma. Although TGF-β was also significantly higher in patients who required admission, ER visit, and short-term burst of oral steroid, FeNO and serum periostin did not show such relationships. The levels of TGF-β tended to be higher in child-onset asthma without outgrow and inversely correlated with age of onset and %FEV1 in such patients.
(Conclusions) The significant relationship between the level of serum TGF-β and the mode of onset, exacerbation, and fixed airflow limitation was observed, suggesting the detrimental roles of TGF-β in asthma pathology. As other established biomarkers did not show such relationships, TGF-β might serve as an independent biomarker for asthma.
Author Block: S. Miyoshi1, H. Nagase1, M. Ujino1, A. Ito1, H. Sakasegawa1, T. Esaki1, K. Kobayashi1, Y. Koizumi1, Y. Tanaka1, N. Sugimoto2, M. Kuramochi1, H. Arai1, M. Yamaguchi1, K. Ohta3; 1Division of Respiratory Medicine and Allergology, Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan, 2Department of Respiratory Medicine, Kanto Central Hospital for Public School Teachers, Tokyo, Japan, 3Tokyo National Hospital, Tokyo, Japan.
(Background) Transforming Growth Factor (TGF)-β is a fibrogenic factor, which may induce airway remodeling in asthma. In contrast, TGF-β also has an immunosuppressive role by inducing the differentiation of regulatory T cells. To date, the significance of measuring TGF-β in asthma has not been established yet. In this study, we investigated the relationship between the level of serum TGF-β and clinical background and other established biomarkers in asthma.
(Methods) Patients were recruited from the outpatient clinic of Teikyo University Hospital (n=243). The levels of serum TGF-β was measured by ELISA and the relationship between serum TGF-β and patient background, asthma control test (ACT) score, pulmonary function, peripheral eosinophil count, FeNO, and serum periostin was investigated.
(Results) The level of serum TGF-β was significantly higher in atopic asthma. Although TGF-β was also significantly higher in patients who required admission, ER visit, and short-term burst of oral steroid, FeNO and serum periostin did not show such relationships. The levels of TGF-β tended to be higher in child-onset asthma without outgrow and inversely correlated with age of onset and %FEV1 in such patients.
(Conclusions) The significant relationship between the level of serum TGF-β and the mode of onset, exacerbation, and fixed airflow limitation was observed, suggesting the detrimental roles of TGF-β in asthma pathology. As other established biomarkers did not show such relationships, TGF-β might serve as an independent biomarker for asthma.
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