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Can RDW Be a Prognostic Factor in Patients with Stable and Acute Exacerbation of COPD Who Do Not Have Any Cardiovascular Disease?
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A4772 - Can RDW Be a Prognostic Factor in Patients with Stable and Acute Exacerbation of COPD Who Do Not Have Any Cardiovascular Disease?
Author Block: U. Yilmaz1, O. Batum2, S. Ermin1, U. Tapan1; 1dr suat seren chest diseases and surgery education and research hospital, Izmir, Turkey, 2Dr. Suat Seren Chest diseases and surgery education and research hospital, Izmir, Turkey.
Ratıonale : Chronic Obstructive Pulmonary Disease (COPD) is a progressive disease that reduces the lifespan of patients. Inflammation plays an important role in its pathogenesis and progression. In this study, we aimed to compare Red blood cell distribution width (RDW) levels as an inflammatory marker in patients with stable and acute exacerbation of COPD who do not have any cardiovascular disease and to investigate its effect on the exacerbation and prognosis of COPD. Methods: The demographic characteristics, smoking, alcohol consumption, RDW, hemoglobin, leukocyte, platelet, biochemical parameters and CRP levels of the patients were recorded. All patients underwent pulmonary function test and echocardiography. Patients who had cardiovascular disease, diabetes mellitus, hypertension, anemia, chronic liver disease and received blood transfusions within the last 2 weeks were excluded from the study. Results : Of the patients, 57 (71.3%) had stable COPD and 23 (28.8%) had acute exacerbation of COPD. The mean age was 64.8±11.6 years. A total of 80 patients were included in the study. In patients with stable COPD, the number of those with GOLD A-B and with GOLD C-D was respectively 26 (45.6%) and 31 (54.3%). In patients with acute exacerbation of COPD, the number of those with GOLD A-B and with GOLD C-D was respectively 5 (21.7%) and 18 (78.2%). In patients with stable COPD, RDW levels at days 0 and 30 were respectively 15±1.6% and 15±1.69%. In patients with acute exacerbation of COPD, RDW levels at days 0 and 30 were respectively 15.2 ±2.4% and 15±2.2%. There was no statistically significant difference between the patients with stable COPD and with acute exacerbation of COPD in terms of RDW levels at days 0 and 30 (respectively, p=0.819 and p=0.647). In those with GOLD A-B, RDW levels at days 0 and 30 were respectively 14.5±1.3% and 14.4±1.5%. In those with GOLD C-D, RDW levels at days 0 and 30 were respectively 15.3±2.1% and 15.3±1.9%. There was no statistically significant difference between those with GOLD A-B and with GOLD C-D in terms of RDW levels at days 0 and 30 (p=0.365 and p=0.735 respectively). Conclusion: There is a need for studies to be conducted with a larger number of patients for use of RDW (a low cost indicator) in daily clinical practice in order to evaluate increased inflammation and to predict acute attack in COPD patients.
Author Block: U. Yilmaz1, O. Batum2, S. Ermin1, U. Tapan1; 1dr suat seren chest diseases and surgery education and research hospital, Izmir, Turkey, 2Dr. Suat Seren Chest diseases and surgery education and research hospital, Izmir, Turkey.
Ratıonale : Chronic Obstructive Pulmonary Disease (COPD) is a progressive disease that reduces the lifespan of patients. Inflammation plays an important role in its pathogenesis and progression. In this study, we aimed to compare Red blood cell distribution width (RDW) levels as an inflammatory marker in patients with stable and acute exacerbation of COPD who do not have any cardiovascular disease and to investigate its effect on the exacerbation and prognosis of COPD. Methods: The demographic characteristics, smoking, alcohol consumption, RDW, hemoglobin, leukocyte, platelet, biochemical parameters and CRP levels of the patients were recorded. All patients underwent pulmonary function test and echocardiography. Patients who had cardiovascular disease, diabetes mellitus, hypertension, anemia, chronic liver disease and received blood transfusions within the last 2 weeks were excluded from the study. Results : Of the patients, 57 (71.3%) had stable COPD and 23 (28.8%) had acute exacerbation of COPD. The mean age was 64.8±11.6 years. A total of 80 patients were included in the study. In patients with stable COPD, the number of those with GOLD A-B and with GOLD C-D was respectively 26 (45.6%) and 31 (54.3%). In patients with acute exacerbation of COPD, the number of those with GOLD A-B and with GOLD C-D was respectively 5 (21.7%) and 18 (78.2%). In patients with stable COPD, RDW levels at days 0 and 30 were respectively 15±1.6% and 15±1.69%. In patients with acute exacerbation of COPD, RDW levels at days 0 and 30 were respectively 15.2 ±2.4% and 15±2.2%. There was no statistically significant difference between the patients with stable COPD and with acute exacerbation of COPD in terms of RDW levels at days 0 and 30 (respectively, p=0.819 and p=0.647). In those with GOLD A-B, RDW levels at days 0 and 30 were respectively 14.5±1.3% and 14.4±1.5%. In those with GOLD C-D, RDW levels at days 0 and 30 were respectively 15.3±2.1% and 15.3±1.9%. There was no statistically significant difference between those with GOLD A-B and with GOLD C-D in terms of RDW levels at days 0 and 30 (p=0.365 and p=0.735 respectively). Conclusion: There is a need for studies to be conducted with a larger number of patients for use of RDW (a low cost indicator) in daily clinical practice in order to evaluate increased inflammation and to predict acute attack in COPD patients.
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