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A Novel Respiratory Impedance-Based Phenotyping and Its Longitudinal Changes in COPD
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A3899 - A Novel Respiratory Impedance-Based Phenotyping and Its Longitudinal Changes in COPD
Author Block: Y. Matsuo1, E. Ogawa2, R. Yukimura1, T. Murayama1, Y. Higami1, D. Kinose1, M. Yamaguchi1, M. Oosawa1, Y. Nakano1; 1Division of Respiratory Medicine, Department of Medicine, Shiga University of Medical Science, Otsu, Japan, 2Health Administration Center, Shiga University of Medical Science, Otsu, Japan.
Background; Forced oscillation technique (FOT) is a non-invasive method for measuring respiratory impedance. We hypothesized that the data from FOT could reflect the pathophysiological changes of patients with chronic obstructive pulmonary disease (COPD). Methods; A total of 106 COPD patients (8 females and 98 males) and 20 non-COPD patients (2 females and 18 males) were enrolled from the outpatient clinic of respiratory medicine in our hospital from August 2013 to July 2014 and were followed up for 2 years. The patients underwent FOT, spirometry and chest CT at baseline and follow-up. Results; The distribution of GOLD (Global Initiative for Chronic Obstructive Lung Disease) 1, 2, 3, and 4 in the COPD patients were 34.9%, 46.2%, 14.2% and 4.7% at baseline, respectively. When the R5 and X5 data of non-COPD patients were used as cutoff, the COPD patients were divided into four phenotypes: the resistance dominant group (RD), the reactance dominant group (XD), the mixed group (MIX), and the normal group (NL). At baseline, XD and MIX had lower FEV1 compare to NL and RD significantly. There were significant differences in the percentage of low attenuation voxels (LAV%) and the square root of airway wall area of the hypothetical airway with an internal perimeter of 10 mm (√Aaw at Pi10) between NL and MIX. The proportion of NL and RD was observed only in the GOLD 1and 2, whereas the GOLD 4 was only consisted of MIX. XD was observed in the Gold 1 to 3 and the percentages were increased as the severity of airflow limitation worsened. After 2 years follow-up, half of RD changed to NL and half remained. Most of XD changed to MIX. Most of all NL and MIX remained each groups. Conclusion; This novel FOT-based phenotype reflected the severity of pulmonary function and may be useful for the assessment of disease progression or the effects of treatments.
Author Block: Y. Matsuo1, E. Ogawa2, R. Yukimura1, T. Murayama1, Y. Higami1, D. Kinose1, M. Yamaguchi1, M. Oosawa1, Y. Nakano1; 1Division of Respiratory Medicine, Department of Medicine, Shiga University of Medical Science, Otsu, Japan, 2Health Administration Center, Shiga University of Medical Science, Otsu, Japan.
Background; Forced oscillation technique (FOT) is a non-invasive method for measuring respiratory impedance. We hypothesized that the data from FOT could reflect the pathophysiological changes of patients with chronic obstructive pulmonary disease (COPD). Methods; A total of 106 COPD patients (8 females and 98 males) and 20 non-COPD patients (2 females and 18 males) were enrolled from the outpatient clinic of respiratory medicine in our hospital from August 2013 to July 2014 and were followed up for 2 years. The patients underwent FOT, spirometry and chest CT at baseline and follow-up. Results; The distribution of GOLD (Global Initiative for Chronic Obstructive Lung Disease) 1, 2, 3, and 4 in the COPD patients were 34.9%, 46.2%, 14.2% and 4.7% at baseline, respectively. When the R5 and X5 data of non-COPD patients were used as cutoff, the COPD patients were divided into four phenotypes: the resistance dominant group (RD), the reactance dominant group (XD), the mixed group (MIX), and the normal group (NL). At baseline, XD and MIX had lower FEV1 compare to NL and RD significantly. There were significant differences in the percentage of low attenuation voxels (LAV%) and the square root of airway wall area of the hypothetical airway with an internal perimeter of 10 mm (√Aaw at Pi10) between NL and MIX. The proportion of NL and RD was observed only in the GOLD 1and 2, whereas the GOLD 4 was only consisted of MIX. XD was observed in the Gold 1 to 3 and the percentages were increased as the severity of airflow limitation worsened. After 2 years follow-up, half of RD changed to NL and half remained. Most of XD changed to MIX. Most of all NL and MIX remained each groups. Conclusion; This novel FOT-based phenotype reflected the severity of pulmonary function and may be useful for the assessment of disease progression or the effects of treatments.
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