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The Relationship Between Mean Corpuscular Hemoglobin Concentration (MCHC) Levels and 30-Day Mortality in Patients with COPD Exacerbation
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A3131 - The Relationship Between Mean Corpuscular Hemoglobin Concentration (MCHC) Levels and 30-Day Mortality in Patients with COPD Exacerbation
Author Block: H. Nakano, Y. Minegishi, H. Machida, K. Sato, M. Kobayashi, M. Nishiwaki, T. Kimura, K. Yamauchi, Y. Tokairin, A. Igarashi, S. Inoue, Y. Shibata; Department of Cardiology, Pulmonology and Nephrology, Yamagata University School of Medicine, Yamagata, Japan.
Background and objectives: Elevated red blood cell distribution width (RDW) levels are associated with increased mortality risk in patients with stable chronic obstructive pulmonary disease (COPD). We have previously reported that a lower serum iron levels are associated with rapid decline of FEV1 in smoking men among a Japanese general population. However, it is unknown how fluctuates the amount of hemoglobin in erythrocytes such as mean corpuscular hemoglobin concentration (MCHC) in patients with COPD in which RDW is increasing. We aimed to investigate the relationship of the level of MCHC with the prognosis of patients with COPD exacerbation. Methods: This is retrospective case-control study. We enrolled 217 patients who admitted to our hospital because of COPD exacerbation from January 2010 to July 2017. Blood samples were obtained at admission or during the early morning within 24 h after admission. We investigated the medical records of the patients, compared the data between deceased and non-deceased patients, and analyzed the relationship between the data and 30-day mortality. Results: Average age was 76.8 years old. 92.4% of patients were men. Twenty patients (9.5%) died within 30 days. MCHC and RDW was significantly lower and higher in deceased patients, respectively. In univariate analysis, total protein, albumin, urea nitrogen, B-type natriuretic peptide (BNP), MCHC and platelet were associated with 30-day mortality, but RDW not. In multivariate analysis, BNP and MCHC were independently associated with 30-day mortality. In the patients having high RDW (≥ 13.9%) and low MCHC (≤32.4 g/dL), the 30-day mortality was highest among the patients with COPD exacerbation. Conclusion: Lower MCHC levels were associated with increased 30-day mortality risk in patients with COPD exacerbation. Evaluation of MCHC in addition to RDW can be expected to improve the prognostic evaluation of COPD exacerbated patients.
Author Block: H. Nakano, Y. Minegishi, H. Machida, K. Sato, M. Kobayashi, M. Nishiwaki, T. Kimura, K. Yamauchi, Y. Tokairin, A. Igarashi, S. Inoue, Y. Shibata; Department of Cardiology, Pulmonology and Nephrology, Yamagata University School of Medicine, Yamagata, Japan.
Background and objectives: Elevated red blood cell distribution width (RDW) levels are associated with increased mortality risk in patients with stable chronic obstructive pulmonary disease (COPD). We have previously reported that a lower serum iron levels are associated with rapid decline of FEV1 in smoking men among a Japanese general population. However, it is unknown how fluctuates the amount of hemoglobin in erythrocytes such as mean corpuscular hemoglobin concentration (MCHC) in patients with COPD in which RDW is increasing. We aimed to investigate the relationship of the level of MCHC with the prognosis of patients with COPD exacerbation. Methods: This is retrospective case-control study. We enrolled 217 patients who admitted to our hospital because of COPD exacerbation from January 2010 to July 2017. Blood samples were obtained at admission or during the early morning within 24 h after admission. We investigated the medical records of the patients, compared the data between deceased and non-deceased patients, and analyzed the relationship between the data and 30-day mortality. Results: Average age was 76.8 years old. 92.4% of patients were men. Twenty patients (9.5%) died within 30 days. MCHC and RDW was significantly lower and higher in deceased patients, respectively. In univariate analysis, total protein, albumin, urea nitrogen, B-type natriuretic peptide (BNP), MCHC and platelet were associated with 30-day mortality, but RDW not. In multivariate analysis, BNP and MCHC were independently associated with 30-day mortality. In the patients having high RDW (≥ 13.9%) and low MCHC (≤32.4 g/dL), the 30-day mortality was highest among the patients with COPD exacerbation. Conclusion: Lower MCHC levels were associated with increased 30-day mortality risk in patients with COPD exacerbation. Evaluation of MCHC in addition to RDW can be expected to improve the prognostic evaluation of COPD exacerbated patients.
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