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Prior Pulmonary Tuberculosis In Chronic Obstructive Pulmonary Disease (COPD) Is Associated with Mortality and Occurrence of Radiological Bronchiectasis
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A3250 - Prior Pulmonary Tuberculosis In Chronic Obstructive Pulmonary Disease (COPD) Is Associated with Mortality and Occurrence of Radiological Bronchiectasis
Author Block: P. Tiew1, J. H. Tan1, R. Soh1, K. Tan1, T. Ong1, T. S. Lapperre1, S. H. Chotirmall2, M. Koh1; 1Respiratory and critical care medicine, Singapore General Hospital, Singapore, Singapore, 2Lee Kong Chian School of Medicine, Singapore, Singapore.
Introduction: Pulmonary tuberculosis (PTB) is a common comorbidity in COPD patients in countries across Asia including Singapore. A history of PTB is associated with increased exacerbations, poorer lung function and earlier COPD onset. We evaluated the association between prior PTB and COPD outcomes in a Singaporean population with COPD. Methods: Patients attending the Singapore General Hospital COPD clinic from 2013 to 2017 were included. Clinical data including demographics, comorbidities, and hospitalization history for COPD were obtained from a prospectively collected Redcap database. Follow up data on mortality were obtained from the hospital electronic record systems. Results: N=200 patients were included with a mean age of 71±8.5 years, mean post-bronchodilator FEV1 of 53.5±17.8 % predicted and FEV1/FVC ratio of 53.0 ±10.0. Follow up period was 26.5±12 months. A total of n=32 (16%) patients had a history of PTB. Prior history of PTB was associated with higher mortality (28.1% vs 12.5%; p=0.032) at follow up when compared to COPD without a history of PTB. No significance difference in age; FEV1, exacerbation history and COPD assessment test (CAT) score was detectable between the groups. Radiological bronchiectasis was detected in 10.5% of patients (n=21) and this was commoner in those with a previous history of PTB (39% vs 14%; p=0.014). Conclusion: High numbers of our COPD cohort had prior PTB. A history of PTB was associated with greater mortality and the presence of radiological bronchiectasis. These findings have relevance for countries where PTB infection is endemic. Funding: PYT is supported by the Singapore Ministry of Health’s National Medical Research Council under its Research Training Fellowship (NMRC/Fellowship/0049/2017) and SHC is supported by the Singapore Ministry of Education under its Singapore Ministry of Education Academic Research Fund Tier 1 (2016-T1-001-050).
Author Block: P. Tiew1, J. H. Tan1, R. Soh1, K. Tan1, T. Ong1, T. S. Lapperre1, S. H. Chotirmall2, M. Koh1; 1Respiratory and critical care medicine, Singapore General Hospital, Singapore, Singapore, 2Lee Kong Chian School of Medicine, Singapore, Singapore.
Introduction: Pulmonary tuberculosis (PTB) is a common comorbidity in COPD patients in countries across Asia including Singapore. A history of PTB is associated with increased exacerbations, poorer lung function and earlier COPD onset. We evaluated the association between prior PTB and COPD outcomes in a Singaporean population with COPD. Methods: Patients attending the Singapore General Hospital COPD clinic from 2013 to 2017 were included. Clinical data including demographics, comorbidities, and hospitalization history for COPD were obtained from a prospectively collected Redcap database. Follow up data on mortality were obtained from the hospital electronic record systems. Results: N=200 patients were included with a mean age of 71±8.5 years, mean post-bronchodilator FEV1 of 53.5±17.8 % predicted and FEV1/FVC ratio of 53.0 ±10.0. Follow up period was 26.5±12 months. A total of n=32 (16%) patients had a history of PTB. Prior history of PTB was associated with higher mortality (28.1% vs 12.5%; p=0.032) at follow up when compared to COPD without a history of PTB. No significance difference in age; FEV1, exacerbation history and COPD assessment test (CAT) score was detectable between the groups. Radiological bronchiectasis was detected in 10.5% of patients (n=21) and this was commoner in those with a previous history of PTB (39% vs 14%; p=0.014). Conclusion: High numbers of our COPD cohort had prior PTB. A history of PTB was associated with greater mortality and the presence of radiological bronchiectasis. These findings have relevance for countries where PTB infection is endemic. Funding: PYT is supported by the Singapore Ministry of Health’s National Medical Research Council under its Research Training Fellowship (NMRC/Fellowship/0049/2017) and SHC is supported by the Singapore Ministry of Education under its Singapore Ministry of Education Academic Research Fund Tier 1 (2016-T1-001-050).
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