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Pulmonary Vasoreactivity to Oxygen in Pulmonary Hypertension Due to Chronic Lung Disease
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A5717 - Pulmonary Vasoreactivity to Oxygen in Pulmonary Hypertension Due to Chronic Lung Disease
Author Block: K. Kusaka1, Y. Morio2, S. Yamamoto1, K. Takeda2, M. Ohgiya3, M. Kawashima1, K. Masuda4, K. Ohta2; 1The Center for Pulmonary Diseases, National Hospital Organization Tokyo National Hospital, Kiyose City, Japan, 2The Center for Pulmonary Diseases, National Hospital Organization Tokyo National Hospital, Tokyo, Japan, 3Center for Pulmonary Diseases, National Hospital Organization Tokyo National Hospital, Kiyose City, Japan, 4The Center for Pulmonary Diseases, National Hospital Organization Tokyo National Hospital, KIYOSE-SHI, Japan.
Background: Pulmonary hypertension due to chronic lung disease (PH-lung) has been demonstrated a poorer outcome compared to pulmonary arterial hypertension (PAH). While PAH-specific therapy is not usually recommended, long-term oxygen therapy is the standard treatment for PH-lung. However, acute vasoreactivity to oxygen inhalation is unclear in severe PH-lung.
Methods: Six patients with severe PH-lung who underwent right heart catheterization (RHC) were retrospectively examined changes in pulmonary hemodynamics before and after oxygen inhalation of 10L/min.
Results: The baseline pulmonary hemodynamics were as follows; mean pulmonary artery pressure (PAPm) 33.8±7.2 mmHg; pulmonary vascular resistance (PVR) 567±102 dyn/S/cm5; cardiac index (CI) 2.01±0.28 L/min/m2. Mixed venous oxygen pressure was decreased at 30.1±2.9 mmHg. PAP and PVR were not altered at change of 8.7±7.4 % and 0.5±18.0 % (p > 0.05), respectively, before and after oxygen inhalation.
Conclusion: Pulmonary vasoreactivity to oxygen inhalation may be blunted in PH-lung with cardiac dysfunction at CI less than 2.5 L/min/m2.
Author Block: K. Kusaka1, Y. Morio2, S. Yamamoto1, K. Takeda2, M. Ohgiya3, M. Kawashima1, K. Masuda4, K. Ohta2; 1The Center for Pulmonary Diseases, National Hospital Organization Tokyo National Hospital, Kiyose City, Japan, 2The Center for Pulmonary Diseases, National Hospital Organization Tokyo National Hospital, Tokyo, Japan, 3Center for Pulmonary Diseases, National Hospital Organization Tokyo National Hospital, Kiyose City, Japan, 4The Center for Pulmonary Diseases, National Hospital Organization Tokyo National Hospital, KIYOSE-SHI, Japan.
Background: Pulmonary hypertension due to chronic lung disease (PH-lung) has been demonstrated a poorer outcome compared to pulmonary arterial hypertension (PAH). While PAH-specific therapy is not usually recommended, long-term oxygen therapy is the standard treatment for PH-lung. However, acute vasoreactivity to oxygen inhalation is unclear in severe PH-lung.
Methods: Six patients with severe PH-lung who underwent right heart catheterization (RHC) were retrospectively examined changes in pulmonary hemodynamics before and after oxygen inhalation of 10L/min.
Results: The baseline pulmonary hemodynamics were as follows; mean pulmonary artery pressure (PAPm) 33.8±7.2 mmHg; pulmonary vascular resistance (PVR) 567±102 dyn/S/cm5; cardiac index (CI) 2.01±0.28 L/min/m2. Mixed venous oxygen pressure was decreased at 30.1±2.9 mmHg. PAP and PVR were not altered at change of 8.7±7.4 % and 0.5±18.0 % (p > 0.05), respectively, before and after oxygen inhalation.
Conclusion: Pulmonary vasoreactivity to oxygen inhalation may be blunted in PH-lung with cardiac dysfunction at CI less than 2.5 L/min/m2.
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