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A Study on the Role of Adiponectin in the Progression of Chronic Obstructive Pulmonary Disease
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A3125 - A Study on the Role of Adiponectin in the Progression of Chronic Obstructive Pulmonary Disease
Author Block: T. Ibaraki1, K. Tomoda1, N. Fujioka1, T. Jinta2, Y. Yamamoto1, M. Yamauchi1, M. Yoshikawa1; 1Department of Respiratory Medicine, Nara Medical University, Kashihara, Japan, 2St. Luke's International Hospital, Tokyo, Japan.
[Background] Recently it has been demonstrated there is a diversity in progression in lung function in COPD. However the precise mechanism has not been cleared. Adiponectin, one of the adipocytokines, has been proved to be related with progression in COPD. Here we report on the relationship between adiponectin and the progression in lung function of COPD. [Subjects and Method] 186 outpatients with stable COPD were enrolled to this study. The relationship between plasma adiponectin levels and 1) clinical findings (FEV1, LAA (Goddard score), BMI), 2) rate of decline in FEV1 (ml/year) before and after measure of adiponectin, 3) prognosis was evaluated. [Results] 1) Adiponectin levels significantly negative correlated with FEV1 and BMI, while they significantly correlated with LAA score. However there was no correlation between the adiponectin levels and rate of FEV1 decline before and after measurement of adiponectin. 2) Adiponectin level in died patients was significantly higher than in survived patients. [Conclusion] Adiponectin may be related with clinical findings and prognosis while it may not be related with progression in lung function.
Author Block: T. Ibaraki1, K. Tomoda1, N. Fujioka1, T. Jinta2, Y. Yamamoto1, M. Yamauchi1, M. Yoshikawa1; 1Department of Respiratory Medicine, Nara Medical University, Kashihara, Japan, 2St. Luke's International Hospital, Tokyo, Japan.
[Background] Recently it has been demonstrated there is a diversity in progression in lung function in COPD. However the precise mechanism has not been cleared. Adiponectin, one of the adipocytokines, has been proved to be related with progression in COPD. Here we report on the relationship between adiponectin and the progression in lung function of COPD. [Subjects and Method] 186 outpatients with stable COPD were enrolled to this study. The relationship between plasma adiponectin levels and 1) clinical findings (FEV1, LAA (Goddard score), BMI), 2) rate of decline in FEV1 (ml/year) before and after measure of adiponectin, 3) prognosis was evaluated. [Results] 1) Adiponectin levels significantly negative correlated with FEV1 and BMI, while they significantly correlated with LAA score. However there was no correlation between the adiponectin levels and rate of FEV1 decline before and after measurement of adiponectin. 2) Adiponectin level in died patients was significantly higher than in survived patients. [Conclusion] Adiponectin may be related with clinical findings and prognosis while it may not be related with progression in lung function.
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