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Quantitative MRI Measurements to Detect Pulmonary Hypertension in Bronchopulomnary Dysplasia
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A6983 - Quantitative MRI Measurements to Detect Pulmonary Hypertension in Bronchopulomnary Dysplasia
Author Block: K. Förster1, B. Ertl-Wagner2, S. Sass3, S. Stoecklein2, F. Schoeppe2, O. Dietrich2, A. Pomschar2, A. Schulze1, C. Huebener4, F. Theis3, H. Ehrhardt5, A. Flemmer1, A. Hilgendorff6; 1Neonatology, Dr. v. Hauner Children`s Hospital, München, Germany, 2Radiology, Ludwig-Maximilian University Hospital Munich, München, Germany, 3Helmholtz Zentrum München, München, Germany, 4Perinatal Center Grosshadern, Clinic for Gynecology and Obstetrics, München, Germany, 5Neonatology, Children`s Hospital of the University Clinic Giessen and Marburg, Giessen, Germany, 6Comprehensive Pneumology Center, Helmholtz Zentrum Muenchen, Munich, Germany.
Background: Pulmonary Hypertension (PH) in Bronchopulmonary dysplasia (BPD)
adversely affects long-term outcome for preterm infants, and is currently diagnosed
by echocardiography or right heart catherisation. Detection and more specific
diagnosis by the use of advanced functional lung imaging techniques, respectively,
would enable initiation of a personalized treatment strategy and especially disease
monitoring.
Methods: We prospectively enrolled 39 infants (28,0 (24,1-30,6) weeks mean
gestational age (GA)). Magnetic resonance imaging (MRI) was performed in
spontaneously breathing infants with an advanced protocol at 3 Tesla at the study
site. Statistical analysis included penalized logistic regression and principal
component analysis.
Results: Quantitative MRI changes in lungs of infants with BPD were detectable at
the time of current clinical diagnosis at corrected 36 weeks postmenstrual age with
characteristically PA-Flow and RV-hypertrophy.
Conclusions: The detection and quantification of lung disease and dysfunction in
infants with PH in BPD by the use of imaging equivalents provides a critical advance
towards accurate diagnosis of Pulmonary Hypertension in BPD enabling early
treatment initiation and monitoring.
Author Block: K. Förster1, B. Ertl-Wagner2, S. Sass3, S. Stoecklein2, F. Schoeppe2, O. Dietrich2, A. Pomschar2, A. Schulze1, C. Huebener4, F. Theis3, H. Ehrhardt5, A. Flemmer1, A. Hilgendorff6; 1Neonatology, Dr. v. Hauner Children`s Hospital, München, Germany, 2Radiology, Ludwig-Maximilian University Hospital Munich, München, Germany, 3Helmholtz Zentrum München, München, Germany, 4Perinatal Center Grosshadern, Clinic for Gynecology and Obstetrics, München, Germany, 5Neonatology, Children`s Hospital of the University Clinic Giessen and Marburg, Giessen, Germany, 6Comprehensive Pneumology Center, Helmholtz Zentrum Muenchen, Munich, Germany.
Background: Pulmonary Hypertension (PH) in Bronchopulmonary dysplasia (BPD)
adversely affects long-term outcome for preterm infants, and is currently diagnosed
by echocardiography or right heart catherisation. Detection and more specific
diagnosis by the use of advanced functional lung imaging techniques, respectively,
would enable initiation of a personalized treatment strategy and especially disease
monitoring.
Methods: We prospectively enrolled 39 infants (28,0 (24,1-30,6) weeks mean
gestational age (GA)). Magnetic resonance imaging (MRI) was performed in
spontaneously breathing infants with an advanced protocol at 3 Tesla at the study
site. Statistical analysis included penalized logistic regression and principal
component analysis.
Results: Quantitative MRI changes in lungs of infants with BPD were detectable at
the time of current clinical diagnosis at corrected 36 weeks postmenstrual age with
characteristically PA-Flow and RV-hypertrophy.
Conclusions: The detection and quantification of lung disease and dysfunction in
infants with PH in BPD by the use of imaging equivalents provides a critical advance
towards accurate diagnosis of Pulmonary Hypertension in BPD enabling early
treatment initiation and monitoring.
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