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Preliminary Exploratory Analysis of Non- Influenza Respiratory Viral Infections (NIRVIs) Among Inpatients at a Tertiary Teaching Hospital in NewYork
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A5536 - Preliminary Exploratory Analysis of Non- Influenza Respiratory Viral Infections (NIRVIs) Among Inpatients at a Tertiary Teaching Hospital in NewYork
Author Block: D. Sharma1, A. Khalil2, A. Avula1; 1Staten Island University Hospital, Staten Island, NY, United States, 2Staten Island University Hospital, Staten island, NY, United States.
Introduction: Non-influenza viruses (NIV) can cause substantial morbidity and have been linked to respiratory failure, especially among patients with underlying cystic fibrosis, asthma, COPD and immunosuppression. Despite this, NIRVIs have not received similar attention as influenza, partly due to lack of prospective trials and dearth of treatment options. With the introduction of rapid diagnostics such as respiratory viral panel-polymerase chain reaction (RSVP-PCR), NIVs are being increasingly diagnosed. The purpose of this study is to explore the burden of NIVs and assess clinical outcomes among those presenting with respiratory symptoms.
Methods: We carried out a retrospective chart review of 100 inpatients from 2015 -16 with NIV, isolated by RSVP-PCR. Primary outcomes were mortality and length of stay (LOS) while secondary outcomes included intensive care unit admission, complications and readmission. Differences in normally distributed continuous variables were analyzed using Student's t test or ANOVA methods. Comparisons of skewed data were analyzed using non-parametric Mann-Whitney and Kruskal-Wallis methods. The χ2 or Fisher's exact test were used to compare categorical outcome variables. Statistical tests were 2-sided and conducted at 0.05 level of significance, utilizing SAS® System Version 9.3.
Results: Respiratory syncital virus (RSV) was most common virus isolated (38 %), followed by rhinovirus/enterovirus (27%), coronavirus (16%), metapneumovirus (MPV) (10%),and prainfluenza virus (9%). 11% presented with acute respiratory failure while 23% required ICU admission for ARDs (7%), Sepsis (7%) and septic shock (9 %). Infection with corona virus was associated with higher number of ICU admissions (33%) while RSV virus had highest mortality rate (6%). 30% patients stayed in hospital for an average of 10 days, with highest LOS in parainfluenza group. Five patients died within a week of admission secondary to shock from superimposed infection. About 6 % patients required readmission within 30 days mainly for uncontrolled copd and heart disease.
Conclusion: Our preliminary data highlights a high prevalence of NIRVIs, associated with adverse outcomes among inpatients. More studies are needed to better understand outcomes associated with NIVs.
Author Block: D. Sharma1, A. Khalil2, A. Avula1; 1Staten Island University Hospital, Staten Island, NY, United States, 2Staten Island University Hospital, Staten island, NY, United States.
Introduction: Non-influenza viruses (NIV) can cause substantial morbidity and have been linked to respiratory failure, especially among patients with underlying cystic fibrosis, asthma, COPD and immunosuppression. Despite this, NIRVIs have not received similar attention as influenza, partly due to lack of prospective trials and dearth of treatment options. With the introduction of rapid diagnostics such as respiratory viral panel-polymerase chain reaction (RSVP-PCR), NIVs are being increasingly diagnosed. The purpose of this study is to explore the burden of NIVs and assess clinical outcomes among those presenting with respiratory symptoms.
Methods: We carried out a retrospective chart review of 100 inpatients from 2015 -16 with NIV, isolated by RSVP-PCR. Primary outcomes were mortality and length of stay (LOS) while secondary outcomes included intensive care unit admission, complications and readmission. Differences in normally distributed continuous variables were analyzed using Student's t test or ANOVA methods. Comparisons of skewed data were analyzed using non-parametric Mann-Whitney and Kruskal-Wallis methods. The χ2 or Fisher's exact test were used to compare categorical outcome variables. Statistical tests were 2-sided and conducted at 0.05 level of significance, utilizing SAS® System Version 9.3.
Results: Respiratory syncital virus (RSV) was most common virus isolated (38 %), followed by rhinovirus/enterovirus (27%), coronavirus (16%), metapneumovirus (MPV) (10%),and prainfluenza virus (9%). 11% presented with acute respiratory failure while 23% required ICU admission for ARDs (7%), Sepsis (7%) and septic shock (9 %). Infection with corona virus was associated with higher number of ICU admissions (33%) while RSV virus had highest mortality rate (6%). 30% patients stayed in hospital for an average of 10 days, with highest LOS in parainfluenza group. Five patients died within a week of admission secondary to shock from superimposed infection. About 6 % patients required readmission within 30 days mainly for uncontrolled copd and heart disease.
Conclusion: Our preliminary data highlights a high prevalence of NIRVIs, associated with adverse outcomes among inpatients. More studies are needed to better understand outcomes associated with NIVs.
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