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Prognostic Factors in Patients with Chronic Pulmonary Aspergillosis
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A5528 - Prognostic Factors in Patients with Chronic Pulmonary Aspergillosis
Author Block: K. Furuhashi, S. Sakurai, Y. Kamiya, H. Yasui, M. Karayama, Y. Suzuki, H. Hozumi, N. Enomoto, T. Fujisawa, Y. Nakamura, N. Inui, T. Suda; 2nd Divison, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Rationale: Chronic pulmonary aspergillosis (CPA) is a chronic infectious and progressive lung destruction disease. Although CPA often has a poor prognosis, there have been a few reports on CPA. The aim of this study is to evaluate the clinical characteristics and prognostic factors in patients with CPA. Methods: We reviewed forty-seven CPA patients (mean age 67.9 years, male 74.5%) from 2011 to 2017. We examined mortality, their clinical characteristics, and prognostic factors retrospectively. Results: The patients were followed up for a mean 35.4 months, and eight patients (17.0%) were dead. All of them died within two years after diagnosis. The survival rate was 88.1% at a year, 81.3% at two years, and at 76.8% at five years. Univariate cox proportional hazard regression analysis showed that cancer patients (yes, Hazard Ratio 6.34, 95% Confidence Interval 1.22−47.8, p value=0.03), serum albumin levels (1g/dl, HR 0.12, 95%CI 0.02−0.50, p=0.003), c-reactive protein levels (1mg/dl, HR 1.38, 95%CI 1.14−1.70, p=0.001), and %VC (1%, HR 0.96, 95%CI 0.91−0.99, p=0.04) were significantly associated with poor prognosis in CPA patients. Conclusions: CPA patients had a poor outcome within two years after diagnosis. The risk factors for the poor prognosis were cancer patients, low albumin, high c-reactive protein, and decreased %VC.
Author Block: K. Furuhashi, S. Sakurai, Y. Kamiya, H. Yasui, M. Karayama, Y. Suzuki, H. Hozumi, N. Enomoto, T. Fujisawa, Y. Nakamura, N. Inui, T. Suda; 2nd Divison, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Rationale: Chronic pulmonary aspergillosis (CPA) is a chronic infectious and progressive lung destruction disease. Although CPA often has a poor prognosis, there have been a few reports on CPA. The aim of this study is to evaluate the clinical characteristics and prognostic factors in patients with CPA. Methods: We reviewed forty-seven CPA patients (mean age 67.9 years, male 74.5%) from 2011 to 2017. We examined mortality, their clinical characteristics, and prognostic factors retrospectively. Results: The patients were followed up for a mean 35.4 months, and eight patients (17.0%) were dead. All of them died within two years after diagnosis. The survival rate was 88.1% at a year, 81.3% at two years, and at 76.8% at five years. Univariate cox proportional hazard regression analysis showed that cancer patients (yes, Hazard Ratio 6.34, 95% Confidence Interval 1.22−47.8, p value=0.03), serum albumin levels (1g/dl, HR 0.12, 95%CI 0.02−0.50, p=0.003), c-reactive protein levels (1mg/dl, HR 1.38, 95%CI 1.14−1.70, p=0.001), and %VC (1%, HR 0.96, 95%CI 0.91−0.99, p=0.04) were significantly associated with poor prognosis in CPA patients. Conclusions: CPA patients had a poor outcome within two years after diagnosis. The risk factors for the poor prognosis were cancer patients, low albumin, high c-reactive protein, and decreased %VC.
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