Home
|
Inbox
|
Search
|
View Abstract
The Development of Lung Cancer During Follow-Up of Patients with Mycobacterium Avium Complex Lung Disease
Description
.abstract img { width:300px !important; height:auto; display:block; text-align:center; margin-top:10px } .abstract { overflow-x:scroll } .abstract table { width:100%; display:block; border:hidden; border-collapse: collapse; margin-top:10px } .abstract td, th { border-top: 1px solid #ddd; padding: 4px 8px; } .abstract tbody tr:nth-child(even) td { background-color: #efefef; } .abstract a { overflow-wrap: break-word; word-wrap: break-word; }
A1983 - The Development of Lung Cancer During Follow-Up of Patients with Mycobacterium Avium Complex Lung Disease
Author Block: T. Kusumoto1, T. Asakura1, S. Suzuki1, S. Okamori1, H. Namkoong1, H. Fujiwara2, K. Yagi1, H. Kamata1, M. Ishii1, T. Betsuyaku1, N. Hasegawa2; 1Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan, 2Center for Infectious Diseases and Infection Control, Keio University School of Medicine, Tokyo, Japan.
Rationale: The prevalence of non-tuberculous mycobacteria (NTM) infection has increased, and Mycobacterium avium complex lung disease (MAC-LD) is the most common type of lung disease in Japan. Some reports have highlighted the co-existence of lung cancer and MAC-LD; however, little is known about the development of the former during the follow-up in MAC-LD patients. The purpose of this study was to clarify the characteristics of lung cancer in MAC-LD patients.Methods: We identified patients who developed lung cancer during MAC-LD follow-up using two sources: the prospective observational cohort registry of patients aged ≥ 20 years from June 2012 to January 2017 at Keio University Hospital, and retrospective identification based on the International Classification of Diseases, tenth revision (ICD-10), between January 2010 and May 2012. We also calculated lung cancer incidence in MAC-LD patients using the prospective observational cohort registry. Results: Seven patients (two men and five women, none of whom had a history of smoking) who developed lung cancer during follow-up for MAC-LD were included in this study. Three were identified from the prospective observational cohort registry (n=280; 227 women; 254 never smokers and 26 former smokers; all patients underwent a chest computed tomography (CT) at least once a year) and four from the retrospective chart review. The incidence rate of lung cancer during MAC-LD follow-up was 106.8 per 100,000 patient-years. The mean age for MAC-LD and lung cancer diagnosis was 63.6 and 75.0 years, respectively. Of the seven patients, six had nodular-bronchiectasis (NB), while one had fibro-cavitary (FC) disease. In four of the seven patients, lung cancer developed in the same lobe affected by MAC-LD. Six patients had adenocarcinoma and one patient had squamous-cell carcinoma. Clinical staging according to the TNM classification system (8th edition) showed that six patients had stage IA disease and one patient had stage IVB disease. Of the six patients with stage IA disease, three patients underwent resection, two received radiotherapy, and one received best supportive care. Conclusions: We identified the clinical characteristics of seven patients with no history of smoking who developed lung cancer during the follow-up for MAC-LD. Periodic follow up with chest CT might result in favorable outcomes.
Author Block: T. Kusumoto1, T. Asakura1, S. Suzuki1, S. Okamori1, H. Namkoong1, H. Fujiwara2, K. Yagi1, H. Kamata1, M. Ishii1, T. Betsuyaku1, N. Hasegawa2; 1Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan, 2Center for Infectious Diseases and Infection Control, Keio University School of Medicine, Tokyo, Japan.
Rationale: The prevalence of non-tuberculous mycobacteria (NTM) infection has increased, and Mycobacterium avium complex lung disease (MAC-LD) is the most common type of lung disease in Japan. Some reports have highlighted the co-existence of lung cancer and MAC-LD; however, little is known about the development of the former during the follow-up in MAC-LD patients. The purpose of this study was to clarify the characteristics of lung cancer in MAC-LD patients.Methods: We identified patients who developed lung cancer during MAC-LD follow-up using two sources: the prospective observational cohort registry of patients aged ≥ 20 years from June 2012 to January 2017 at Keio University Hospital, and retrospective identification based on the International Classification of Diseases, tenth revision (ICD-10), between January 2010 and May 2012. We also calculated lung cancer incidence in MAC-LD patients using the prospective observational cohort registry. Results: Seven patients (two men and five women, none of whom had a history of smoking) who developed lung cancer during follow-up for MAC-LD were included in this study. Three were identified from the prospective observational cohort registry (n=280; 227 women; 254 never smokers and 26 former smokers; all patients underwent a chest computed tomography (CT) at least once a year) and four from the retrospective chart review. The incidence rate of lung cancer during MAC-LD follow-up was 106.8 per 100,000 patient-years. The mean age for MAC-LD and lung cancer diagnosis was 63.6 and 75.0 years, respectively. Of the seven patients, six had nodular-bronchiectasis (NB), while one had fibro-cavitary (FC) disease. In four of the seven patients, lung cancer developed in the same lobe affected by MAC-LD. Six patients had adenocarcinoma and one patient had squamous-cell carcinoma. Clinical staging according to the TNM classification system (8th edition) showed that six patients had stage IA disease and one patient had stage IVB disease. Of the six patients with stage IA disease, three patients underwent resection, two received radiotherapy, and one received best supportive care. Conclusions: We identified the clinical characteristics of seven patients with no history of smoking who developed lung cancer during the follow-up for MAC-LD. Periodic follow up with chest CT might result in favorable outcomes.
|
Home
|
Inbox
|
Search
|