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Comparison of Characteristics of COPD Patients Caused by Biomass Smoke Exposure and Cigarette Smoke Exposure
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A1712 - Comparison of Characteristics of COPD Patients Caused by Biomass Smoke Exposure and Cigarette Smoke Exposure
Author Block: H. Joo1, C. Yeo1, K. Yoo2, K. Jung3, H. Yoon4, C. Rhee1; 1Internal medicine, The Catholic University of Korea, Seoul, Korea, Republic of, 2Mayo Clinic/konkuk University, Rochester, MN, United States, 3Hallym Univ Sacred Heart Hosp, Kyunggi 431-070, Korea, Republic of, 4The Catholic University of Korea, Seoul, Korea, Republic of.
Background: Biomass smoke is a risk factor for the development of airflow obstruction and chronic obstructive pulmonary disease, especially in developing countries. Cigarette smoking is the most important risk factor for Chronic Obstructive Pulmonary Disease (COPD) in developed countries. COPD due to biomass smoke is still not well characterized, and it might be differ in some aspects from COPD caused by cigarette smoking. We aimed to compare the characteristics of COPD patients with biomass smoke exposed and cigarette smoke exposed. Methods: We identified all female outpatients diagnosed with COPD at Seoul St. Mary’s Hospital between Jan 2013 and May 2017. And, from a Korean COPD Subtype Study (KOCOSS) cohort, we selected female patients with cigarette smoke exposed. Clinical characteristics were compared between two groups. Results: 84 female COPD patients with biomass exposure and 40 female smokers with COPD patients without biomass exposure from Seoul St. Mary’s Hospital and KOCOSS cohort were enrolled in this study. The mean cumulative exposure of biomass for the biomass smoke exposure group was 65.36 hour-years and cumulative exposure of tobacco for cigarette smoke exposure groups was 29.77 pack-years. The post-bronchodilator FEV1 was 70.45%±19.15% predicted in biomass group and 65.79%±11.42% predicted in smoke group (p=0.208). The post-bronchodilator FEV1/FVC ratio was 58.94±10.25 in biomass group and 53.79±11.42 in smoke group (p=0.021). DLCO was 77.85±21.08 in biomass group and 65.34±19.97 in smoke group (p=0.006). There was no significant difference of severe exacerbation rate and proportion of chronic bronchitis phenotype in both group. There were no significant differences between the two groups with respect to inhaler uses: ICS/LABA; ICS; LABA; LAMA; LABA/LAMA; or Triple therapy. There was a difference in pulmonary function, but there was no difference in medication use.Conclusion: Biomass COPD group and smoke COPD group have different lung functions. Further studies regarding the characteristics of COPD with biomass exposure are required.
Author Block: H. Joo1, C. Yeo1, K. Yoo2, K. Jung3, H. Yoon4, C. Rhee1; 1Internal medicine, The Catholic University of Korea, Seoul, Korea, Republic of, 2Mayo Clinic/konkuk University, Rochester, MN, United States, 3Hallym Univ Sacred Heart Hosp, Kyunggi 431-070, Korea, Republic of, 4The Catholic University of Korea, Seoul, Korea, Republic of.
Background: Biomass smoke is a risk factor for the development of airflow obstruction and chronic obstructive pulmonary disease, especially in developing countries. Cigarette smoking is the most important risk factor for Chronic Obstructive Pulmonary Disease (COPD) in developed countries. COPD due to biomass smoke is still not well characterized, and it might be differ in some aspects from COPD caused by cigarette smoking. We aimed to compare the characteristics of COPD patients with biomass smoke exposed and cigarette smoke exposed. Methods: We identified all female outpatients diagnosed with COPD at Seoul St. Mary’s Hospital between Jan 2013 and May 2017. And, from a Korean COPD Subtype Study (KOCOSS) cohort, we selected female patients with cigarette smoke exposed. Clinical characteristics were compared between two groups. Results: 84 female COPD patients with biomass exposure and 40 female smokers with COPD patients without biomass exposure from Seoul St. Mary’s Hospital and KOCOSS cohort were enrolled in this study. The mean cumulative exposure of biomass for the biomass smoke exposure group was 65.36 hour-years and cumulative exposure of tobacco for cigarette smoke exposure groups was 29.77 pack-years. The post-bronchodilator FEV1 was 70.45%±19.15% predicted in biomass group and 65.79%±11.42% predicted in smoke group (p=0.208). The post-bronchodilator FEV1/FVC ratio was 58.94±10.25 in biomass group and 53.79±11.42 in smoke group (p=0.021). DLCO was 77.85±21.08 in biomass group and 65.34±19.97 in smoke group (p=0.006). There was no significant difference of severe exacerbation rate and proportion of chronic bronchitis phenotype in both group. There were no significant differences between the two groups with respect to inhaler uses: ICS/LABA; ICS; LABA; LAMA; LABA/LAMA; or Triple therapy. There was a difference in pulmonary function, but there was no difference in medication use.Conclusion: Biomass COPD group and smoke COPD group have different lung functions. Further studies regarding the characteristics of COPD with biomass exposure are required.
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