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Analysis of the Pathological Distribution of Lung Cancer and Survival Trends in Lincolnshire Over a 2 Year Period
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A7345 - Analysis of the Pathological Distribution of Lung Cancer and Survival Trends in Lincolnshire Over a 2 Year Period
Author Block: M. N. Okoye, Dr Ayushman Gupta, Dr Ahmed, Dr Ade Oyegoke, Dr Bassey Asuquo; Respiratory, Pilgrim Hospital, Boston, United Kingdom.
Introduction:
Recent advancement in diagnosis and treatment of lung cancer is the concept of personalise medicine, where therapeutic decisions are made based on patient specific histological and genetic characteristic of their Lung cancer. A retrospective review of pathological diagnosis of Lung cancer within our Trust and our survival trend.
Method:
We decided to review our lung cancer register from the 3 major hospitals within the United Lincolnshire NHS Trust. These Hospitals were Pilgrim Hospital Boston, Lincoln County Hospital and Grantham District Hospital. All cases within our Lung cancer registry were reviewed to determine cases with definite pathological diagnosis and those without as well as survival rate of our patients.
Result:
A total of 895 patients had a diagnosis of lung cancer over that period but only 584(65%) individual cases had a pathological classification. Others were labelled as lung cancer but no pathological diagnosis attached to them. Of the cases of definite pathological diagnosis the distribution of the 3 Hospitals was; Pilgrim hospital 317 cases, Lincoln Hospital 227 cases, Grantham District Hospital 40 cases. The distribution of the types of lung cancer was as follows:- Adenocarcinoma 177 cases [30.3%], Squamous cell carcinoma 178 cases[30.5%], Adeno-squamous cell only 1 case[0.002%], Carcinoid 4 cases[0.007%], Mesothelioma 36 cases[0.06%], Large cell neuroendocrine 16 cases[0.03%], Small cell 75 cases[0.13%] , Mixed tumour 5 cases[0.009%]. A total of 88[0.15%] cases were labelled as Non-small cell carcinoma and only one case as just carcinoma. Regarding the survival trends during within the period in question 246 patients [0.27%] of 895 patients was still alive at the time, of those still alive only 188 [76.4%] have a pathological diagnosis with 58[0.24%] without any pathological diagnosis.
Conclusion:
The pathological distribution of lung cancer within the Lincolnshire County was very similar to the 2015 National lung cancer audit findings for the United Kingdom. The study also showed that having a definite pathological diagnosis had a profound effect on survival of patients and they also had a better clinical outcome because they could be offered surgery, radiotherapy, first-line or second-line targeted chemotherapy depending on the stage of their lung cancer.
References:
1)
Introduction to the 2015 World Health Organization Classification of Tumors of the Lung, Pleura,Thymus and Heart.[J Thorac Oncology 2015}
2)
Royal College of Physicians. National Lung Cancer Audit annual report 2016 (for the audit period 2015). London: Royal College of Physicians, 2017.
Author Block: M. N. Okoye, Dr Ayushman Gupta, Dr Ahmed, Dr Ade Oyegoke, Dr Bassey Asuquo; Respiratory, Pilgrim Hospital, Boston, United Kingdom.
Introduction:
Recent advancement in diagnosis and treatment of lung cancer is the concept of personalise medicine, where therapeutic decisions are made based on patient specific histological and genetic characteristic of their Lung cancer. A retrospective review of pathological diagnosis of Lung cancer within our Trust and our survival trend.
Method:
We decided to review our lung cancer register from the 3 major hospitals within the United Lincolnshire NHS Trust. These Hospitals were Pilgrim Hospital Boston, Lincoln County Hospital and Grantham District Hospital. All cases within our Lung cancer registry were reviewed to determine cases with definite pathological diagnosis and those without as well as survival rate of our patients.
Result:
A total of 895 patients had a diagnosis of lung cancer over that period but only 584(65%) individual cases had a pathological classification. Others were labelled as lung cancer but no pathological diagnosis attached to them. Of the cases of definite pathological diagnosis the distribution of the 3 Hospitals was; Pilgrim hospital 317 cases, Lincoln Hospital 227 cases, Grantham District Hospital 40 cases. The distribution of the types of lung cancer was as follows:- Adenocarcinoma 177 cases [30.3%], Squamous cell carcinoma 178 cases[30.5%], Adeno-squamous cell only 1 case[0.002%], Carcinoid 4 cases[0.007%], Mesothelioma 36 cases[0.06%], Large cell neuroendocrine 16 cases[0.03%], Small cell 75 cases[0.13%] , Mixed tumour 5 cases[0.009%]. A total of 88[0.15%] cases were labelled as Non-small cell carcinoma and only one case as just carcinoma. Regarding the survival trends during within the period in question 246 patients [0.27%] of 895 patients was still alive at the time, of those still alive only 188 [76.4%] have a pathological diagnosis with 58[0.24%] without any pathological diagnosis.
Conclusion:
The pathological distribution of lung cancer within the Lincolnshire County was very similar to the 2015 National lung cancer audit findings for the United Kingdom. The study also showed that having a definite pathological diagnosis had a profound effect on survival of patients and they also had a better clinical outcome because they could be offered surgery, radiotherapy, first-line or second-line targeted chemotherapy depending on the stage of their lung cancer.
References:
1)
Introduction to the 2015 World Health Organization Classification of Tumors of the Lung, Pleura,Thymus and Heart.[J Thorac Oncology 2015}
2)
Royal College of Physicians. National Lung Cancer Audit annual report 2016 (for the audit period 2015). London: Royal College of Physicians, 2017.
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