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Is Advanced Age a Prognostic Factor for Adjuvant Chemotherapy in Completely Resected Non-Small-Cell Lung Cancer (NSCLC)?
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A7354 - Is Advanced Age a Prognostic Factor for Adjuvant Chemotherapy in Completely Resected Non-Small-Cell Lung Cancer (NSCLC)?
Author Block: O. Batum, C. Anar, Y. Ozdogan, S. Ermin, U. Yilmaz; Dr. Suat Seren Chest diseases and surgery education and research hospital, Izmir, Turkey.
Rationale: The influence of advanced age on patients with non-small-cell lung cancer (NSCLC) undergoing adjuvant chemotherapy after surgical treatment is controversial. The aim of this study is to investigate the effects of age and other clinical variables on survival in patients with NSCLC undergoing adjuvant chemotherapy (CT) after complete surgical resection. Methods: Patients with NSCLC who were primarily completely resected and underwent adjuvant chemotherapy between January 2012 and January 2016 were included in the study. The effects of clinical variables such as predictive value of age 65, gender, tumor histology, pT stage, pN stage, pTNM stage, chemotherapy regimen, number of cycles, adjuvant thoracic radiotherapy (TRT), and relapse status on survival were assessed by the log-rank test and the Multivariate Cox regression analysis. Results: 91 patients with NSCLC undergoing adjuvant CT after complete surgical resection were included in the study. The median age of the patients was 60.0 years (95% CI 36.08-73.09). 86% of them were males. Of the patients, 49.4% had squamous NSCLC and 50.6% had non-squamous NSCLC. Moreover, 59% had stage I-II disease and 41% had stage III disease. Patients were divided into two groups according to predictive value of age 65. OS was 61.9 months in patients aged 65 years or younger (95% CI 51.28-72.69) and was 73.1 months in patients older than 65 years (95% CI 60.24-85.94) (p=0.119) (Figure-1A). DFS was 47.0 months in patients aged 65 years or younger (95% CI 37.81-56.23) and was 51.1 months in patients older than 65 years (95% CI 40.68-57.17) (p=0.407). In multivariate Cox regression analysis, pathologic stage III (HR:2.615 (95%CI 1.212-5.617, p=0.014) and presence of recurrence (HR:2.496 (95%CI 1.165-5.368 p=0.019) increased mortality risk by 2 times. Predictive value of age 65 had no effect on survival. Conclusion: Advanced age had no prognostic effect on survival in patients with NSCLC undergoing adjuvant CT after complete surgical resection. However, locally advanced stage and recurrence development indicate poor prognosis.
Author Block: O. Batum, C. Anar, Y. Ozdogan, S. Ermin, U. Yilmaz; Dr. Suat Seren Chest diseases and surgery education and research hospital, Izmir, Turkey.
Rationale: The influence of advanced age on patients with non-small-cell lung cancer (NSCLC) undergoing adjuvant chemotherapy after surgical treatment is controversial. The aim of this study is to investigate the effects of age and other clinical variables on survival in patients with NSCLC undergoing adjuvant chemotherapy (CT) after complete surgical resection. Methods: Patients with NSCLC who were primarily completely resected and underwent adjuvant chemotherapy between January 2012 and January 2016 were included in the study. The effects of clinical variables such as predictive value of age 65, gender, tumor histology, pT stage, pN stage, pTNM stage, chemotherapy regimen, number of cycles, adjuvant thoracic radiotherapy (TRT), and relapse status on survival were assessed by the log-rank test and the Multivariate Cox regression analysis. Results: 91 patients with NSCLC undergoing adjuvant CT after complete surgical resection were included in the study. The median age of the patients was 60.0 years (95% CI 36.08-73.09). 86% of them were males. Of the patients, 49.4% had squamous NSCLC and 50.6% had non-squamous NSCLC. Moreover, 59% had stage I-II disease and 41% had stage III disease. Patients were divided into two groups according to predictive value of age 65. OS was 61.9 months in patients aged 65 years or younger (95% CI 51.28-72.69) and was 73.1 months in patients older than 65 years (95% CI 60.24-85.94) (p=0.119) (Figure-1A). DFS was 47.0 months in patients aged 65 years or younger (95% CI 37.81-56.23) and was 51.1 months in patients older than 65 years (95% CI 40.68-57.17) (p=0.407). In multivariate Cox regression analysis, pathologic stage III (HR:2.615 (95%CI 1.212-5.617, p=0.014) and presence of recurrence (HR:2.496 (95%CI 1.165-5.368 p=0.019) increased mortality risk by 2 times. Predictive value of age 65 had no effect on survival. Conclusion: Advanced age had no prognostic effect on survival in patients with NSCLC undergoing adjuvant CT after complete surgical resection. However, locally advanced stage and recurrence development indicate poor prognosis.
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