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Evaluation of the Incidence and Severity of Cardiac Related Liver Disease in Patients with Pulmonary Arterial Hypertension
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A2120 - Evaluation of the Incidence and Severity of Cardiac Related Liver Disease in Patients with Pulmonary Arterial Hypertension
Author Block: M. Lerche, H. R. Wirtz, T. Karlas, J. Wiegand, A. Frille, V. Keim, H. J. Seyfarth; University of Leipzig, Leipzig, Germany.
Background: Long-term elevation of venous pressure in the hepatic veins may be associated with the development of liver fibrosis or cirrhosis. A differentiated approach regarding the incidence and severity of cardiac related liver disease is missing to date. Methods: In a single-center study of case series, patients with either pulmonary arterial hypertension (PAH) or pulmonary hypertension due to left heart disease (PH-LH) were systematically investigated. Virus hepatitis was excluded and Nonalcoholic fatty liver disease (NAFDL) Score as well as Fibrosis-4 (FIB-4) Index was calculated. To verify liver stiffness, transient elastography (FibroScan®) was used and an ultrasound-based measurement of the controlled attenuated parameter (CAP) as a predicting parameter for steatosis hepatis was performed. Results:To date 36 patients at a mean age of 69 years were determined. 14 patients suffered from PAH (group 1) and 22 patients from PH- LH (group 2). NAFDL Score, FIB-4 Index and CAP were significantly increased in group 2 compared to group 1. Conclusion:TE and measurement of CAP can be applied in patients with cardiac diseases, too. So far, we hypothesize, that incidence and severity of cardiac related liver disease is significantly higher in patients with PH-LH compared to patients with PAH.
Author Block: M. Lerche, H. R. Wirtz, T. Karlas, J. Wiegand, A. Frille, V. Keim, H. J. Seyfarth; University of Leipzig, Leipzig, Germany.
Background: Long-term elevation of venous pressure in the hepatic veins may be associated with the development of liver fibrosis or cirrhosis. A differentiated approach regarding the incidence and severity of cardiac related liver disease is missing to date. Methods: In a single-center study of case series, patients with either pulmonary arterial hypertension (PAH) or pulmonary hypertension due to left heart disease (PH-LH) were systematically investigated. Virus hepatitis was excluded and Nonalcoholic fatty liver disease (NAFDL) Score as well as Fibrosis-4 (FIB-4) Index was calculated. To verify liver stiffness, transient elastography (FibroScan®) was used and an ultrasound-based measurement of the controlled attenuated parameter (CAP) as a predicting parameter for steatosis hepatis was performed. Results:To date 36 patients at a mean age of 69 years were determined. 14 patients suffered from PAH (group 1) and 22 patients from PH- LH (group 2). NAFDL Score, FIB-4 Index and CAP were significantly increased in group 2 compared to group 1. Conclusion:TE and measurement of CAP can be applied in patients with cardiac diseases, too. So far, we hypothesize, that incidence and severity of cardiac related liver disease is significantly higher in patients with PH-LH compared to patients with PAH.
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