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Respiratory Infections in Asthmatic Children in Algeria: Preliminary Data
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A1901 - Respiratory Infections in Asthmatic Children in Algeria: Preliminary Data
Author Block: B. Bouazza, M. Messad, S. Sadi; Biochemistry and Microbiology Department, Mouloud Mammeri Universit of Tizi-Ouzou, Tizi-Ouzou, Algeria.
Background. Asthma is a chronic inflammatory and a complex multifactorial disease. Some factors may exacerbate asthma including respiratory infection. Bacterial infection is well documented in asthma childhood; however, bacterial and fungal co-infection is still not well understood. Objectives. i) To identify and determine the social-environmental risk factors that triggers asthma in chil en and ii) to evaluate the respiratory tract infections (bacterial and fungal) in asthmatic chil en in Tizi-Ouzou city. Methods. Fifty-two asthmatic chil en were recruited and their parent completed a modified ISAAC questionnaire. Patients were aged from 3 to 15 years attending the pediatric department of the Mohamed Nedir University Hospital in Tizi-Ouzou. Sputum samples from 16 asthmatic chil en and 3 non-asthmatic chil en were collected and cultured for bacterial and fungal infection. Results. 55.77% were male. Family history of asthma was found in 63% of patients, and 13.46% were asthmatic parents. More than 50% reported missing one or more days of school and symptoms worsening occur in winter and spring season in 48%. Interestingly, 52% were hospitalized at least one time last year. Sputum analysis showed the presence of white blood cells including eosinophil in 10 samples (> 60%). Bacterial and fungal germs were found in 8 samples including Staphylococcus aureus, Citrobacter freundii, Candida albicans and Candida glabrata. Interestingly, co-infection was found in patients hospitalized four times last year after admission to emergency room. Conclusion. Taken together, our results demonstrated the involvement of several triggers in developing asthma in childhood in Tizi-Ouzou city. The diagnosis of bacterial and fungal infection and its treatment may help to reduce asthma exacerbation in chil en.
Author Block: B. Bouazza, M. Messad, S. Sadi; Biochemistry and Microbiology Department, Mouloud Mammeri Universit of Tizi-Ouzou, Tizi-Ouzou, Algeria.
Background. Asthma is a chronic inflammatory and a complex multifactorial disease. Some factors may exacerbate asthma including respiratory infection. Bacterial infection is well documented in asthma childhood; however, bacterial and fungal co-infection is still not well understood. Objectives. i) To identify and determine the social-environmental risk factors that triggers asthma in chil en and ii) to evaluate the respiratory tract infections (bacterial and fungal) in asthmatic chil en in Tizi-Ouzou city. Methods. Fifty-two asthmatic chil en were recruited and their parent completed a modified ISAAC questionnaire. Patients were aged from 3 to 15 years attending the pediatric department of the Mohamed Nedir University Hospital in Tizi-Ouzou. Sputum samples from 16 asthmatic chil en and 3 non-asthmatic chil en were collected and cultured for bacterial and fungal infection. Results. 55.77% were male. Family history of asthma was found in 63% of patients, and 13.46% were asthmatic parents. More than 50% reported missing one or more days of school and symptoms worsening occur in winter and spring season in 48%. Interestingly, 52% were hospitalized at least one time last year. Sputum analysis showed the presence of white blood cells including eosinophil in 10 samples (> 60%). Bacterial and fungal germs were found in 8 samples including Staphylococcus aureus, Citrobacter freundii, Candida albicans and Candida glabrata. Interestingly, co-infection was found in patients hospitalized four times last year after admission to emergency room. Conclusion. Taken together, our results demonstrated the involvement of several triggers in developing asthma in childhood in Tizi-Ouzou city. The diagnosis of bacterial and fungal infection and its treatment may help to reduce asthma exacerbation in chil en.
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