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Effect of Black Carbon on Blood Pressure: Modification by Obesity and Smoking Status in a Repeated Measures Study
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A1915 - Effect of Black Carbon on Blood Pressure: Modification by Obesity and Smoking Status in a Repeated Measures Study
Author Block: E. S. Baja1, G. V. Dalmacion1, A. D. Ligsay2; 1Institute of Clinical Epidemiology, University of the Philippines Manila, Manila, Philippines, 2Clinical Research Section, St. Luke’s College of Medicine, Quezon City, Philippines.
Introduction: Exposure to traffic-related air pollution has been linked to changes in cardiovascular outcomes, at times within days of exposure. We examined the effect of black carbon (BC) on diastolic (DBP) and systolic (SBP) blood pressure and whether these associations were modified by participant characteristics.
Methods: We studied repeated measurements of SBP and DBP on 158 traffic enforcers from the Metropolitan Manila Development Authority (MMDA) Health Study using mixed-effects models with random intercepts. Hourly central site measurements of ambient black carbon were conducted. We investigated exposure windows during the preceding 1 to 7 days (1- to 7-day lags) before the measurement of SBP and DBP responses for BC.
Results: A 30% (3.13 μg/m3) increase in ambient BC 3 days (3-day lag) before the visit was associated with increased SBP [0.47 mmHg change; 95% confidence interval (CI), 0.08, 0.86]. We found a similar association with DBP for a 30% (3.13 μg/m3) increase in ambient BC 3 days (3-day lag) before the visit (0.24 mmHg change; 95%CI, -0.01, 0.18). For the 3-day lag window, associations were stronger for ever-smokers (0.74 mmHg change in SBP; 95%CI, 0.17, 1.37) and for non-obese (0.55 mmHg change in SBP; 95%CI, 0.12, 0.94) traffic enforcers. We found no statistically significant associations in the other exposure windows.
Conclusions: Exposure to increasing ambient BC, a marker of vehicular-traffic-pollution, may increase SBP and DBP among traffic enforcers who are non-obese; enforcers who are ever-smokers increase this effect.
Author Block: E. S. Baja1, G. V. Dalmacion1, A. D. Ligsay2; 1Institute of Clinical Epidemiology, University of the Philippines Manila, Manila, Philippines, 2Clinical Research Section, St. Luke’s College of Medicine, Quezon City, Philippines.
Introduction: Exposure to traffic-related air pollution has been linked to changes in cardiovascular outcomes, at times within days of exposure. We examined the effect of black carbon (BC) on diastolic (DBP) and systolic (SBP) blood pressure and whether these associations were modified by participant characteristics.
Methods: We studied repeated measurements of SBP and DBP on 158 traffic enforcers from the Metropolitan Manila Development Authority (MMDA) Health Study using mixed-effects models with random intercepts. Hourly central site measurements of ambient black carbon were conducted. We investigated exposure windows during the preceding 1 to 7 days (1- to 7-day lags) before the measurement of SBP and DBP responses for BC.
Results: A 30% (3.13 μg/m3) increase in ambient BC 3 days (3-day lag) before the visit was associated with increased SBP [0.47 mmHg change; 95% confidence interval (CI), 0.08, 0.86]. We found a similar association with DBP for a 30% (3.13 μg/m3) increase in ambient BC 3 days (3-day lag) before the visit (0.24 mmHg change; 95%CI, -0.01, 0.18). For the 3-day lag window, associations were stronger for ever-smokers (0.74 mmHg change in SBP; 95%CI, 0.17, 1.37) and for non-obese (0.55 mmHg change in SBP; 95%CI, 0.12, 0.94) traffic enforcers. We found no statistically significant associations in the other exposure windows.
Conclusions: Exposure to increasing ambient BC, a marker of vehicular-traffic-pollution, may increase SBP and DBP among traffic enforcers who are non-obese; enforcers who are ever-smokers increase this effect.
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