Home
|
Inbox
|
Search
|
View Abstract
Successfully Treated Heparin Induced Thrombocytopenia with Intravenous Immunoglobulin
Description
.abstract img { width:300px !important; height:auto; display:block; text-align:center; margin-top:10px } .abstract { overflow-x:scroll } .abstract table { width:100%; display:block; border:hidden; border-collapse: collapse; margin-top:10px } .abstract td, th { border-top: 1px solid #ddd; padding: 4px 8px; } .abstract tbody tr:nth-child(even) td { background-color: #efefef; } .abstract a { overflow-wrap: break-word; word-wrap: break-word; }
A3426 - Successfully Treated Heparin Induced Thrombocytopenia with Intravenous Immunoglobulin
Author Block: E. Karem1, H. S. Bukamur2, H. Mezughi1, E. Alkhankan3, Y. R. Shweihat4; 1IM, Marshall university, Huntington, WV, United States, 2Pulmonary, Marshall university, Huntington, WV, United States, 3Pulmonary, Marshall University, Huntington, WV, United States, 4Internal Medicine, Marshall University, Huntington, WV, United States.
Heparin-induced thrombocytopenia (HIT) is a potentially devastating autoimmune phenomenon results in platelet consumption and severe thrombotic state. It is treated by heparin discontinuation and initiation of alternative anticoagulation. Use of alternative managements such as Intravenous immunoglobulin(IgG) in the setting of severe thromboembolism and prolonged thrombocytopenia refractory to standard treatment have shown immediate and sustained response. IVIg inhibits HIT antibody- mediated platelet activation. The constant domain (Fc) of IgG plays a critical role but not the antigen-binding portion (Fab). Herein, we present 67yrs old female with a severe HIT refractory to standard treatment (Argatroban) that was successfully treated with intravenous immunoglobulin.
Author Block: E. Karem1, H. S. Bukamur2, H. Mezughi1, E. Alkhankan3, Y. R. Shweihat4; 1IM, Marshall university, Huntington, WV, United States, 2Pulmonary, Marshall university, Huntington, WV, United States, 3Pulmonary, Marshall University, Huntington, WV, United States, 4Internal Medicine, Marshall University, Huntington, WV, United States.
Heparin-induced thrombocytopenia (HIT) is a potentially devastating autoimmune phenomenon results in platelet consumption and severe thrombotic state. It is treated by heparin discontinuation and initiation of alternative anticoagulation. Use of alternative managements such as Intravenous immunoglobulin(IgG) in the setting of severe thromboembolism and prolonged thrombocytopenia refractory to standard treatment have shown immediate and sustained response. IVIg inhibits HIT antibody- mediated platelet activation. The constant domain (Fc) of IgG plays a critical role but not the antigen-binding portion (Fab). Herein, we present 67yrs old female with a severe HIT refractory to standard treatment (Argatroban) that was successfully treated with intravenous immunoglobulin.
|
Home
|
Inbox
|
Search
|