Home
|
Inbox
|
Search
|
View Abstract
Simultaneous Administration of O2 and Prescribed Aerosol Medication Via Oxygen Mask and InspiraChamber® Anti-Static Valved Holding Chamber
Description
.abstract img { width:300px !important; height:auto; display:block; text-align:center; margin-top:10px } .abstract { overflow-x:scroll } .abstract table { width:100%; display:block; border:hidden; border-collapse: collapse; margin-top:10px } .abstract td, th { border-top: 1px solid #ddd; padding: 4px 8px; } .abstract tbody tr:nth-child(even) td { background-color: #efefef; } .abstract a { overflow-wrap: break-word; word-wrap: break-word; }
A2019 - Simultaneous Administration of O2 and Prescribed Aerosol Medication Via Oxygen Mask and InspiraChamber® Anti-Static Valved Holding Chamber
Author Block: R. Toddywala1, M. T. Newhouse2, V. Shukla1, P. Goldman3; 1InspiRx Inc., Somerset, NJ, United States, 2McMaster Faculty of Health Sciences, Hamilton, ON, Canada, 3Lif-O-Gen, Allentown, PA, United States.
Introduction
Asthma is often poorly controlled. Common precipitating factors for acute severe exacerbations include allergens, physical, chemical and biological agents. Asthmatics may rapidly and unexpectedly develop life-threatening disease and occasionally die before first responders can provide adequate rescue therapy. A concern in the past has been that O2 delivered via the Valved Holding Chamber (VHC) mask might flush the bronchodilator aerosol away from the patient’s mouth thus the O2 mask and MDI+VHC were alternated. A solution might be to fit the VHC into the O2 mask so that the aerosol is inhaled while flow of O2 is maintained.
Methods:
The InspiraChamber® Anti-Static VHC (InspiRx Inc., Somerset, NJ) was attached to a CPR-O2 Mask from a Lif-O-Gen® Automated First Aid Oxygen unit (Allied Healthcare, St. Louis, MO). The mask was placed on an adult face model that was connected via USP induction port/throat a to a 7-stage Anderson Cascade Impactor operating at 28.3 L/min. Oxygen/Air was introduced continuously through the CPR Mask at 7 liters per minute. Ten (10) puffs of Ventolin HFA (GSK) were introduced into the InspiraChamber® using a 10 second delay between puffs and samples were analyzed using HPLC. The particle size data were compared with or without oxygen/air flow to determine if there were changes to the drug delivery efficiency of the InspiraChamber®.
Results:
The MMAD, GSD, respirable and total dose of Albuterol were similar for the InspiraChamber® with Lif-O-Gen® CPR O2mask with 7 LPM Air/O2 flow or no Air/O2 flow. The MMAD was an average of 2.5 μ (with airflow) and 2.3 μ (without airflow). Similarly the GSD was an average of 1.5 with or without airflow. The total dose was an average of 14.91 μg/spray (with airflow) and 10.65 μg/spray (without airflow). Finally, the respirable dose (0.5 μ - 5.0 μ) was an average of 12.42 μg/spray (with airflow) and 8.36 μg/spray (without airflow).
Conclusions:
This preliminary study showed that the total delivered dose and particle size profile with and without gas flow through the mask were similar or with gas flow somewhat better and suggests that the InspiraChamber® +albuterol by MDI could be used with supplemental oxygen provided by the Lif-O-Gen® CPR-O2 mask with minimal change or even an increase in the delivered dose.
Author Block: R. Toddywala1, M. T. Newhouse2, V. Shukla1, P. Goldman3; 1InspiRx Inc., Somerset, NJ, United States, 2McMaster Faculty of Health Sciences, Hamilton, ON, Canada, 3Lif-O-Gen, Allentown, PA, United States.
Introduction
Asthma is often poorly controlled. Common precipitating factors for acute severe exacerbations include allergens, physical, chemical and biological agents. Asthmatics may rapidly and unexpectedly develop life-threatening disease and occasionally die before first responders can provide adequate rescue therapy. A concern in the past has been that O2 delivered via the Valved Holding Chamber (VHC) mask might flush the bronchodilator aerosol away from the patient’s mouth thus the O2 mask and MDI+VHC were alternated. A solution might be to fit the VHC into the O2 mask so that the aerosol is inhaled while flow of O2 is maintained.
Methods:
The InspiraChamber® Anti-Static VHC (InspiRx Inc., Somerset, NJ) was attached to a CPR-O2 Mask from a Lif-O-Gen® Automated First Aid Oxygen unit (Allied Healthcare, St. Louis, MO). The mask was placed on an adult face model that was connected via USP induction port/throat a to a 7-stage Anderson Cascade Impactor operating at 28.3 L/min. Oxygen/Air was introduced continuously through the CPR Mask at 7 liters per minute. Ten (10) puffs of Ventolin HFA (GSK) were introduced into the InspiraChamber® using a 10 second delay between puffs and samples were analyzed using HPLC. The particle size data were compared with or without oxygen/air flow to determine if there were changes to the drug delivery efficiency of the InspiraChamber®.
Results:
The MMAD, GSD, respirable and total dose of Albuterol were similar for the InspiraChamber® with Lif-O-Gen® CPR O2mask with 7 LPM Air/O2 flow or no Air/O2 flow. The MMAD was an average of 2.5 μ (with airflow) and 2.3 μ (without airflow). Similarly the GSD was an average of 1.5 with or without airflow. The total dose was an average of 14.91 μg/spray (with airflow) and 10.65 μg/spray (without airflow). Finally, the respirable dose (0.5 μ - 5.0 μ) was an average of 12.42 μg/spray (with airflow) and 8.36 μg/spray (without airflow).
Conclusions:
This preliminary study showed that the total delivered dose and particle size profile with and without gas flow through the mask were similar or with gas flow somewhat better and suggests that the InspiraChamber® +albuterol by MDI could be used with supplemental oxygen provided by the Lif-O-Gen® CPR-O2 mask with minimal change or even an increase in the delivered dose.
|
Home
|
Inbox
|
Search
|