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Serum Lipids and Lipoproteins Quantified by NMR Spectroscopy Are Correlated with FVC, 6MWD and GAP Index in Idiopathic Pulmonary Fibrosis
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A1059 - Serum Lipids and Lipoproteins Quantified by NMR Spectroscopy Are Correlated with FVC, 6MWD and GAP Index in Idiopathic Pulmonary Fibrosis
Author Block: A. V. Barochia1, M. Kaler1, E. M. Gordon1, D. Figueroa1, N. A. Weir2, M. Lemma3, M. Sampson4, A. T. Remaley1, S. Barnett3, G. M. Grant5, S. D. Nathan3, S. J. Levine1; 1NHLBI, National Institutes of Health, Bethesda, MD, United States, 2Medicine, NIH-Inova Advanced Lung Dis Program, Falls Church, VA, United States, 3Inova Fairfax Hospital, Falls Church, VA, United States, 4CC, National Institutes of Health, Bethesda, MD, United States, 5George Mason Univ, Manassas, VA, United States.
Rationale: Forced vital capacity (FVC), 6-minute walk distance (6MWD), and the GAP (Gender Age Physiology) index are clinically relevant outcomes utilized in idiopathic pulmonary fibrosis (IPF) research. Serum lipids have been associated with multiple pulmonary diseases, including IPF. Here, we investigated whether there were any significant associations between serum lipids/lipoproteins and clinical outcomes in IPF patients and healthy volunteers.
Objectives: To determine whether serum lipids or lipoproteins correlate with FVC, 6MWD and GAP index in IPF subjects, as well as healthy volunteers.
Methods: Clinical data and serum lipid assay results (using standard laboratory methods and nuclear magnetic resonance spectroscopy (NMR)) were analyzed from 56 healthy volunteers and 59 subjects with IPF. All subjects provided informed consent to participate in IRB-approved clinical research protocols. Correlations between serum lipids and FVC, 6MWD and GAP index were analyzed using Pearson’s correlation. Multivariable linear regressions incorporating the variables age, sex, race, BMI and CRP-level (defined a priori) were used to further explore these associations.
Results: NMR derived values of total cholesterol (NTC), low-density lipoprotein cholesterol (NLC), and the concentration of small HDL cholesterol particles correlated positively with FVC and 6MWD, and negatively with the GAP index, in IPF subjects by Pearson correlation method. These associations were not observed in the healthy volunteers. The, FVC, 6MWD and GAP index remained significantly associated with NTC and NLC in the IPF subjects even after adjusting for age, sex, race, BMI and CRP levels. In addition, NMR derived apolipoprotein B was also significantly associated with all three clinical outcomes in IPF subjects by multivariable regression.
Conclusions: NMR derived values of serum total cholesterol and LDL cholesterol are positively associated with FVC and 6MWD, and negatively with the GAP index, suggesting that lower serum levels of these lipids or lipoproteins may be a marker of worse clinical outcomes in IPF. Further studies are warranted to explore the role of serum lipids and lipoproteins in IPF pathology, as these relationships are discordant with results from cardiovascular research studies where lower levels of these lipids are associated with better outcomes, such as a decreased risk of developing coronary artery disease.
This research was funded by the Intramural Research Program of the NHLBI (NIH).
Author Block: A. V. Barochia1, M. Kaler1, E. M. Gordon1, D. Figueroa1, N. A. Weir2, M. Lemma3, M. Sampson4, A. T. Remaley1, S. Barnett3, G. M. Grant5, S. D. Nathan3, S. J. Levine1; 1NHLBI, National Institutes of Health, Bethesda, MD, United States, 2Medicine, NIH-Inova Advanced Lung Dis Program, Falls Church, VA, United States, 3Inova Fairfax Hospital, Falls Church, VA, United States, 4CC, National Institutes of Health, Bethesda, MD, United States, 5George Mason Univ, Manassas, VA, United States.
Rationale: Forced vital capacity (FVC), 6-minute walk distance (6MWD), and the GAP (Gender Age Physiology) index are clinically relevant outcomes utilized in idiopathic pulmonary fibrosis (IPF) research. Serum lipids have been associated with multiple pulmonary diseases, including IPF. Here, we investigated whether there were any significant associations between serum lipids/lipoproteins and clinical outcomes in IPF patients and healthy volunteers.
Objectives: To determine whether serum lipids or lipoproteins correlate with FVC, 6MWD and GAP index in IPF subjects, as well as healthy volunteers.
Methods: Clinical data and serum lipid assay results (using standard laboratory methods and nuclear magnetic resonance spectroscopy (NMR)) were analyzed from 56 healthy volunteers and 59 subjects with IPF. All subjects provided informed consent to participate in IRB-approved clinical research protocols. Correlations between serum lipids and FVC, 6MWD and GAP index were analyzed using Pearson’s correlation. Multivariable linear regressions incorporating the variables age, sex, race, BMI and CRP-level (defined a priori) were used to further explore these associations.
Results: NMR derived values of total cholesterol (NTC), low-density lipoprotein cholesterol (NLC), and the concentration of small HDL cholesterol particles correlated positively with FVC and 6MWD, and negatively with the GAP index, in IPF subjects by Pearson correlation method. These associations were not observed in the healthy volunteers. The, FVC, 6MWD and GAP index remained significantly associated with NTC and NLC in the IPF subjects even after adjusting for age, sex, race, BMI and CRP levels. In addition, NMR derived apolipoprotein B was also significantly associated with all three clinical outcomes in IPF subjects by multivariable regression.
Conclusions: NMR derived values of serum total cholesterol and LDL cholesterol are positively associated with FVC and 6MWD, and negatively with the GAP index, suggesting that lower serum levels of these lipids or lipoproteins may be a marker of worse clinical outcomes in IPF. Further studies are warranted to explore the role of serum lipids and lipoproteins in IPF pathology, as these relationships are discordant with results from cardiovascular research studies where lower levels of these lipids are associated with better outcomes, such as a decreased risk of developing coronary artery disease.
This research was funded by the Intramural Research Program of the NHLBI (NIH).
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