Home
|
Inbox
|
Search
|
View Abstract
Small Airway Disease a Potential Feature of Scleroderma Lung Disease
Description
.abstract img { width:300px !important; height:auto; display:block; text-align:center; margin-top:10px } .abstract { overflow-x:scroll } .abstract table { width:100%; display:block; border:hidden; border-collapse: collapse; margin-top:10px } .abstract td, th { border-top: 1px solid #ddd; padding: 4px 8px; } .abstract tbody tr:nth-child(even) td { background-color: #efefef; } .abstract a { overflow-wrap: break-word; word-wrap: break-word; }
A3016 - Small Airway Disease a Potential Feature of Scleroderma Lung Disease
Author Block: L. Pourzand1, G. Kim2, F. Abtin3, D. P. Tashkin4, J. Goldin5; 1Radiology, UCLA, Los Angeles, CA, United States, 2UCLA, Los Angeles, CA, United States, 3Univ of California At Los Angeles, Los Angeles, CA, United States, 4UCLA Sch of Medicine, Los Angeles, CA, United States, 5David Geffen School of Med At UCLA, Santa Monica, CA, United States.
Background: Interstitial lung disease (ILD) and pulmonary hypertension
are the leading causes of morbidity and mortality in systemic sclerosis
(SSc). Presence of small airways disease has been suggested in previous
reports, however it was mainly attributed to smoking related lung disease.
The main objective of the present study is to investigate the prevalence of
small airways disease in SSc patients by visual evaluation of air trapping
on end-expiratory CT scans.
Methods: Baseline volumetric HRCT scans of 155 participants in the
National Institute of Health Funded Scleroderma Lung Study II (a clinical
trial comparing treatment with oral cyclophosphamide versus
Mycophenolate Mofetil) were visually reviewed. Both end-inspiratory and
end-expiratory CTs were reviewed and air trapping was evaluated on the
end-expiratory scan. Air trapping was defined as one or more regions of
low attenuation in 3 adjacent lobules involving one or more lobes.
Results: Out of 155 baseline HRCT scans in SLS II, 18.1% (28 of 155
patients) were excluded due to absence or suboptimal end-expiratory
exam. 1.9 % (3 of 155 patients) were excluded due to the presence of large
airway disease related to emphysema or proximal airway disease. Hence
124 subjects were assessed. Smoking history was available on all subjects.
48.4% (60 of 124 patients) showed air trapping on end-expiratory images
and 51.6% (64 of 124 patients) did not show any air trapping. In our study,
air trapping did not demonstrate any relationship with prior smoking history.
Conclusions: Air trapping suggestive of small airways disease was found
in a substantial proportion of SSc patients. Small airways disease may be a
less known manifestation of scleroderma lung disease and independent of
smoking histories but further studies required to validate these findings.
Author Block: L. Pourzand1, G. Kim2, F. Abtin3, D. P. Tashkin4, J. Goldin5; 1Radiology, UCLA, Los Angeles, CA, United States, 2UCLA, Los Angeles, CA, United States, 3Univ of California At Los Angeles, Los Angeles, CA, United States, 4UCLA Sch of Medicine, Los Angeles, CA, United States, 5David Geffen School of Med At UCLA, Santa Monica, CA, United States.
Background: Interstitial lung disease (ILD) and pulmonary hypertension
are the leading causes of morbidity and mortality in systemic sclerosis
(SSc). Presence of small airways disease has been suggested in previous
reports, however it was mainly attributed to smoking related lung disease.
The main objective of the present study is to investigate the prevalence of
small airways disease in SSc patients by visual evaluation of air trapping
on end-expiratory CT scans.
Methods: Baseline volumetric HRCT scans of 155 participants in the
National Institute of Health Funded Scleroderma Lung Study II (a clinical
trial comparing treatment with oral cyclophosphamide versus
Mycophenolate Mofetil) were visually reviewed. Both end-inspiratory and
end-expiratory CTs were reviewed and air trapping was evaluated on the
end-expiratory scan. Air trapping was defined as one or more regions of
low attenuation in 3 adjacent lobules involving one or more lobes.
Results: Out of 155 baseline HRCT scans in SLS II, 18.1% (28 of 155
patients) were excluded due to absence or suboptimal end-expiratory
exam. 1.9 % (3 of 155 patients) were excluded due to the presence of large
airway disease related to emphysema or proximal airway disease. Hence
124 subjects were assessed. Smoking history was available on all subjects.
48.4% (60 of 124 patients) showed air trapping on end-expiratory images
and 51.6% (64 of 124 patients) did not show any air trapping. In our study,
air trapping did not demonstrate any relationship with prior smoking history.
Conclusions: Air trapping suggestive of small airways disease was found
in a substantial proportion of SSc patients. Small airways disease may be a
less known manifestation of scleroderma lung disease and independent of
smoking histories but further studies required to validate these findings.
|
Home
|
Inbox
|
Search
|