The NSLT showed a 20% reduction in lung cancer mortality with yearly LDCT screening of high-risk patients. Current USPSTF guidelines recommend yearly screening in patients aged 55-80 with a greater than 30 pack-year smoking history who currently smoke or have quit within 15 years. Using a pro-con debate approach, this session will address key questions about patient selection for LDCT screening such as: what is the role for screening in patients with severe COPD, should patient selection for screening be based on guideline criteria or individual risk factors, and should biomarkers be used in determining which patients should undergo screening.