Event

This session will discuss best practice methods to study mitochondrial function in cells and tissues. Mitochondrial function and glycolysis play critical roles in a variety of cellular processes, including cellular activation, proliferation, differentiation, cell death, and disease progression. Specific signatures of mitochondrial dysfunction that are associated with disease pathogenesis and/or progression are becoming increasingly important. In particular, the centrality of mitochondria in the pathological processes and clinical phenotypes associated with a range of lung diseases including chronic obstructive pulmonary disease, pulmonary fibrosis, acute lung injury, asthma and lung cancer is emerging. Understanding the molecular mechanisms regulating the mitochondrial processes of lung cells will help to better define phenotypes and clinical manifestations associated with respiratory disease and to identify potential diagnostic and therapeutic targets. In this session, attendees will discover how real-time, live cell analysis can provide a complete picture of mitochondrial phenotype and function in model systems and in human disease, with a particular focus on diseases area.