Choosing Wisely® and other interventions to reduce low-value healthcare are vital. Yet, de-adoption of unnecessary care has proved difficult, partly due to the challenges of recognizing which patients are actually receiving low-value care. This session emphasizes how de-adoptive practices and personalized medicine can work together to reduce low-value care while also selecting patients likely to benefit from therapies. The session looks at quality of care across pulmonary medicine as leading experts discuss: areas where appropriate therapies are underutilized or misused; cutting-edge research aimed at preventing overuse; and future directions targeted to improve value in healthcare.