Recent discoveries in the clinical and basic science arena have changed the clinical and scientific approach to chronic graft failure after lung transplantation. This session will be of interests to clinicians and researchers alike. New clinical tools to phenotype patients, to improve prognostication, and to tailor therapeutic interventions in chronic lung allograft dysfunction (CLAD) will be discussed. Novel clinical, translational, and basic science methods being employed to further our understanding of CLAD will be reviewed.