The translation of scientific evidence into therapeutic products to treat respiratory diseases and sleep is an exciting yet challenging process. Investigators funded through the Centers for Advanced Diagnostic and Experimental Therapeutics (CADET II) program supported by NHLBI will share their experience in translating their own scientific discoveries into therapeutic products for lung diseases. They will describe the biologic basis for their selected therapeutic targets and their approach to identifying candidate drugs to modify the target, as well as the process of selecting a therapeutic candidate to advance.