The expanding field of Nanotechnology industry is leading to rapid growth in the use of engineered nanomaterials (ENMs) in thousands of consumer products. With subtle variation in physicochemical properties a near infinite number of ENMs can be generated. The widespread use of ENMs in consumer products is a concern for potential unintended exposure to ENMs. The overarching goals of the Nanotechnology Health Implications Research (NHIR) consortium are to gain fundamental understanding on the molecular and pathological pathways involved in the toxicity of ENM-biological interactions for a library of ENMs representing high production, use in consumer products, including emerging two and three dimensional ENMs containing new transitional metals and whose toxicology is unknown. This session will highlight the goals, objectives and ongoing efforts by the NHIR consortium and opportunities for collaboration among materials science and toxicology research community in addressing this important public health issue.