This session will focus on novel and emerging concepts in chronic thromboembolic pulmonary hypertension (CTEPH). The evolution of acute pulmonary embolism (PE) to chronic disease and the epidemiology of CTEPH are poorly defined. Similarly, little is known about the pathologic and pathogenic underpinnings of this disease. Time-tested diagnostic and therapeutic strategies are being challenged by advances in imaging, interventional procedures and medical therapy. This session will address these knowledge gaps by providing novel evidence describing the incidence of CTEPH after acute PE and the importance of collateral circulation in the pathology of CTEPH. Advances in surgical techniques will be reviewed, as well as the emergence of balloon pulmonary angioplasty as a treatment option.