Event

Mitochondria are a chief energy generator and essential to maintain cellular homeostasis, including diverse roles in intracellular signaling that can define cell function and response to external stimuli. Mitochondrial dysfunction has emerged as a significant underpinning for disease pathogenesis, being involved with inflammation, tissue remodeling, and aberrant wound repair. This is associated with aberrant mitochondrial dynamics, response to and regulation of oxidative stress, and altered intracellular calcium flux. This symposium highlights emerging understanding of the breadth and integrated pathobiological responses and roles for mitochondria, as well as the potential for this knowledge to inform development of mitochondria targeting therapies.