Lung cancer screening in highrisk population has been shown to effectively detect early lung cancer in the NLST trial. As such, United States Prevention Service Task Force has given a Grade B recommendation to annual low dose chest computed tomography scan for lung cancer screening. Since this development, there have been an increasing number of pulmonary nodules detected. The American College of Chest Physicians lung cancer guidelines recommended biopsies in patients who have moderate risk or patients who have high risk but desire tissue confirmation prior to resection. As a result, bronchoscopic approaches to reach peripheral lung nodule have become an integral part of the pulmonary practice. Development of navigational bronchoscopy and the use of radial EBUS probe has improved biopsy yield compared to conventional flexible bronchoscopy. Understanding the limitations and best applications of these tools will allow physicians to achieve better yield when diagnosing peripheral lung nodules.