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Transbronchial cryobiopsy (TBCB) is a technique where a cryotherapy probe is advanced to the lung parenchyma via the working channel of a standard bronchoscope following which cold temperatures (<-40° C) are generated at the tip of the probe leading to lung tissue adhesion. The probe and bronchoscope are then removed from the patient retrieving significantly larger pieces of lung tissue than those obtained via traditional transbronchial forceps biopsy (TBBX). TBCB compared to TBBX in patients with diffuse lung disease and showed significantly larger biopsy pieces, more alveolar tissue, and less parenchymal damage/crush artifact. TBCB has recently become more popular for numerous diagnostic indications, with several recent studies suggesting the validity of TBCB for the diagnosis of diffuse parenchymal lung disease. However, the risk of procedural complications such as pneumothorax and moderate to severe bleeding needs to be considered when planning for this procedure.