Pharmacogenomics analyzes how the genetic makeup of an individual affects his/her responses to drugs. It can provide new insights on pathophysiology, focus the use of specific therapies to those who will benefit, and divert use in those in whom risk of harm is too great. There are an increasing number of successful applications of pharmacogenomics in lung diseases. This course will provide an overview of the key aspects in design and analyses of pharmacogenomic studies, some examples of its successful use, and outline some ongoing efforts to implement pharmacogenomic knowledge in clinical medicine.