This session will introduce the microfluidic Living Human Lung Small Airway Chip technology and will explore its application to (1) model pulmonary inflammatory disorders (e.g., COPD, asthma) in vitro, (2) simulate physiological exposure to inhaled particulates and gases (e.g., cigarette smoke, electronic cigarette vapor), and (3) clinically validate these synthetic model systems to enable discovery of novel disease biomarkers and potential druggable targets.