Extracorporeal membrane oxygenation (ECMO) allows for gas exchange and hemodynamic support in patients failing conventional mechanical ventilation and is an evolving way of treating patients with severe respiratory failure. This session will incorporate multidisciplinary didactic and simulation sessions to educate the learner on optimal use of ECMO and tackle the challenges and questions raised surrounding its use, including patient selection, use of the ventilator during ECMO, treating unique patient populations (such as pregnant patients or those awaiting lung transplantation), physical rehabilitation during ECMO, troubleshooting common problems, and others.