The emergence of electronic cigarettes and the legalization of recreational and medical marijuana combined with the high prevalence of cigarette smoking and alcohol misuse bring addiction issues to the forefront of many clinical encounters in pulmonary and critical care medicine. This scientific symposium will focus on areas in which addiction medicine intersects with pulmonary and critical care medicine. The session will bring together outstanding investigators to highlight cutting-edge basic, translational, and clinical investigation and discuss research in a way that can inform bedside conversations in the pulmonary clinic and the intensive care unit.