Our understanding of the genetic basis of pediatric lung disease has advanced exponentially over the past several years. Beyond single-point mutations, research on the determinants of pediatric lung disease has incrementally focused on epigenetic regulation, gene-by-environment interactions, transcriptomic profiling, and other complex mechanisms. In this session, we will discuss the latest developments in the genetics and genomics of childhood asthma, cystic fibrosis, pulmonary hypertension, and bronchopulmonary dysplasia. We will also discuss the clinical implications of these recent findings.