Sex differences exist in pulmonary medicine. Certain diseases present differently in females, have a greater severity compared to males, or affect women almost exclusively. Some disorders have been traditionally viewed as male-specific (COPD) or are rare diseases and diagnostic delays are common. Potential theories include detrimental effects of sex hormones, gender susceptibility and differences in lifestyle. Data also suggests that outcomes differ in females in specific pulmonary diseases. Current guidelines lack tailored approach to diagnose and manage women with pulmonary disorders. Nevertheless, experts in the field believe that more research leading to personalized management is needed to improve outcomes.